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Evaluation of human papillomavirus type 16 viral load and genome physical status in Iranian women with cervical disease

Molecular biology reports, 2024-12, Vol.51 (1), p.411 [Peer Reviewed Journal]

2024. The Author(s), under exclusive licence to Springer Nature B.V. ;EISSN: 1573-4978 ;DOI: 10.1007/s11033-024-09397-6 ;PMID: 38466465

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Title:
Evaluation of human papillomavirus type 16 viral load and genome physical status in Iranian women with cervical disease
Author: Setayeshi, Shadi ; Hasanzadeh, Ali ; Yahyapour, Yousef ; Alizadeh, Ahad ; Ghorbani, Hossein ; Nokhostin, Fahimeh ; Bagheri, Meghdad ; Sadeghi, Farzin
Subjects: DNA, Viral - genetics ; DNA-Binding Proteins - genetics ; Female ; Human papillomavirus 16 - genetics ; Humans ; Iran ; Oncogene Proteins, Viral - genetics ; Papillomavirus Infections ; Precancerous Conditions ; Uterine Cervical Neoplasms - pathology ; Viral Load - genetics
Is Part Of: Molecular biology reports, 2024-12, Vol.51 (1), p.411
Description: This study examined the viral load and physical status of the human papillomavirus 16 (HPV-16) genome in non-cancerous, precancerous and cancerous cervical lesions. Quantitative real-time PCR was performed to determine HPV-16 E2 and E6 viral load in 132 cervical specimens. E2/E6 viral load ratio was used to determine the physical status of HPV-16 genome. E2 gene viral load was a significant (P < 0.001) predicting biomarker in differentiating non-cancerous from precancerous and cancerous samples. E6 gene viral load was significantly different between the groups (P < 0.001). The specificity and sensitivity of E2 and E6 in distinguishing SCC samples were 100% and 95% respectively. HPV-16 viral load measured through E2 and E6 genes is a reliable indicator of lesion type.
Publisher: Netherlands
Language: English
Identifier: EISSN: 1573-4978
DOI: 10.1007/s11033-024-09397-6
PMID: 38466465
Source: MEDLINE

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Evaluation of human papillomavirus type 16 viral load and genome physical status in Iranian women with cervical disease

2024. The Author(s), under exclusive licence to Springer Nature B.V. ;EISSN: 1573-4978 ;DOI: 10.1007/s11033-024-09397-6 ;PMID: 38466465

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