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Retinal vein occlusion as an age‐dependent marker of incident dementia in a long‐term Danish national cohort

Acta ophthalmologica (Oxford, England), 2024-06, Vol.102 (4), p.455-461 [Peer Reviewed Journal]

2023 The Authors. published by John Wiley & Sons Ltd on behalf of Acta Ophthalmologica Scandinavica Foundation. ;2023 The Authors. Acta Ophthalmologica published by John Wiley & Sons Ltd on behalf of Acta Ophthalmologica Scandinavica Foundation. ;2023. This article is published under http://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;ISSN: 1755-375X ;EISSN: 1755-3768 ;DOI: 10.1111/aos.15797 ;PMID: 37874264

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Title:
Retinal vein occlusion as an age‐dependent marker of incident dementia in a long‐term Danish national cohort
Author: Clausen, Anna Rebien ; Stokholm, Lonny ; Frederiksen, Katrine Hartmund ; Möller, Sören ; Blaabjerg, Morten ; Pedersen, Frederik Nørregaard ; Grauslund, Jakob
Subjects: Age ; Age Factors ; Aged ; Aged, 80 and over ; Alzheimer's disease ; cohort study ; Comorbidity ; Dementia ; Dementia - diagnosis ; Dementia - epidemiology ; Dementia disorders ; Denmark - epidemiology ; Female ; Follow-Up Studies ; Humans ; Incidence ; Male ; Occlusion ; ocular biomarkers ; Prospective Studies ; register‐based study ; Registries ; Regression analysis ; Retina ; retinal vein occlusion ; Retinal Vein Occlusion - diagnosis ; Retinal Vein Occlusion - epidemiology ; Risk Factors ; Vascular dementia
Is Part Of: Acta ophthalmologica (Oxford, England), 2024-06, Vol.102 (4), p.455-461
Description: Purpose The aim of this study was to investigate retinal vein occlusion (RVO) as an independent marker of incident dementia. Methods In a prospective nationwide cohort study, we identified 2 225 568 individuals through the Danish national health registers. Individuals older than 65 years, without unspecified retinal vascular occlusion or dementia were included from 1998 to 2020 and followed until 2022. We calculated the incidence rate (IR) and performed a Cox regression analysis with a hazard ratio (HR) and 95% confidence interval (CI) for RVO (exposure) as a marker of all‐cause dementia adjusted for systemic comorbidity. Results We identified 19 669 individuals with RVO who had a higher prevalence of systemic comorbidity at inclusion compared to those without RVO (n = 2 185 483). We performed a Cox regression analysis for age‐dependent exposure due to non‐proportional hazards in the pre‐planned analysis. Exposed individuals younger than 75 years had an increased risk of all‐cause dementia (adjusted HR 1.09, 95% CI 1.01–1.18), whereas individuals older than 75 years had a decreased risk of all‐cause dementia (adjusted HR 0.92, 95% CI 0.86–0.98). Conclusion Individuals with RVO had an age‐dependent risk of dementia, with a 9% increased risk in individuals with RVO younger than 75 years and an 8% decreased risk in individuals older than 75 years at the time of exposure.
Publisher: England: Wiley Subscription Services, Inc
Language: English
Identifier: ISSN: 1755-375X
EISSN: 1755-3768
DOI: 10.1111/aos.15797
PMID: 37874264
Source: MEDLINE

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Retinal vein occlusion as an age‐dependent marker of incident dementia in a long‐term Danish national cohort

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