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Radio-anatomical evaluation of clinical and radiomic profile of multi-parametric magnetic resonance imaging of de novo glioblastoma multiforme

Journal of Egyptian National Cancer Institute, 2024-12, Vol.36 (1), p.13-10 [Peer Reviewed Journal]

The Author(s) 2024 ;2024. The Author(s). ;COPYRIGHT 2024 Springer ;The Author(s) 2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;ISSN: 1110-0362 ;EISSN: 2589-0409 ;DOI: 10.1186/s43046-024-00217-3 ;PMID: 38644430

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Title:
Radio-anatomical evaluation of clinical and radiomic profile of multi-parametric magnetic resonance imaging of de novo glioblastoma multiforme
Author: Ahmed, H. Shafeeq ; Devaraj, Trupti ; Singhvi, Maanini ; Dasan, T. Arul ; Ranganath, Priya
Subjects: Adult ; Aged ; Brain cancer ; Brain Neoplasms - diagnostic imaging ; Brain Neoplasms - pathology ; Brain tumors ; Correlation analysis ; Datasets ; Female ; Females ; Glioblastoma ; Glioblastoma - diagnostic imaging ; Glioblastoma - pathology ; Glioblastoma multiforme ; Glioma ; Humans ; Magnetic resonance imaging ; Magnetic Resonance Imaging - methods ; Male ; Males ; Medical imaging ; Medical prognosis ; Medical research ; Medicine ; Medicine & Public Health ; Medicine, Experimental ; Middle Aged ; MRI ; Multiparametric Magnetic Resonance Imaging ; Mutation ; Neuro-oncology ; Neuroimaging ; Neurology ; Oncology ; Prognosis ; Radiology ; Radiomics ; Retrospective Studies ; Sociodemographics ; Tumors
Is Part Of: Journal of Egyptian National Cancer Institute, 2024-12, Vol.36 (1), p.13-10
Description: Background Glioblastoma (GBM) is a fatal, fast-growing, and aggressive brain tumor arising from glial cells or their progenitors. It is a primary malignancy with a poor prognosis. The current study aims at evaluating the neuroradiological parameters of de novo GBM by analyzing the brain multi-parametric magnetic resonance imaging (mpMRI) scans acquired from a publicly available database analysis of the scans. Methods The dataset used was the mpMRI scans for de novo glioblastoma (GBM) patients from the University of Pennsylvania Health System, called the UPENN-GBM dataset. This was a collection from The Cancer Imaging Archive (TCIA), a part of the National Cancer Institute. The MRIs were reviewed by a single diagnostic radiologist, and the tumor parameters were recorded, wherein all recorded data was corroborated with the clinical findings. Results The study included a total of 58 subjects who were predominantly male (male:female ratio of 1.07:1). The mean age with SD was 58.49 (11.39) years. Mean survival days with SD were 347 (416.21) days. The left parietal lobe was the most commonly found tumor location with 11 (18.96%) patients. The mean intensity for T1, T2, and FLAIR with SD was 1.45E + 02 (20.42), 1.11E + 02 (17.61), and 141.64 (30.67), respectively ( p = < 0.001). The tumor dimensions of anteroposterior, transverse, and craniocaudal gave a z-score (significance level = 0.05) of − 2.53 ( p = 0.01), − 3.89 ( p < 0.001), and 1.53 ( p = 0.12), respectively. Conclusion The current study takes a third-party database and reduces physician bias from interfering with study findings. Further prospective and retrospective studies are needed to provide conclusive data.
Publisher: Berlin/Heidelberg: Springer Berlin Heidelberg
Language: English
Identifier: ISSN: 1110-0362
EISSN: 2589-0409
DOI: 10.1186/s43046-024-00217-3
PMID: 38644430
Source: GFMER Free Medical Journals
MEDLINE
ProQuest Central
DOAJ Directory of Open Access Journals
Springer Nature OA Free Journals

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Radio-anatomical evaluation of clinical and radiomic profile of multi-parametric magnetic resonance imaging of de novo glioblastoma multiforme

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