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Age-associated physiological and pathological changes at the blood–brain barrier: A review

Journal of Cerebral Blood Flow & Metabolism, 2017-01, Vol.37 (1), p.4-24 [Peer Reviewed Journal]

The Author(s) 2016 ;The Author(s) 2016. ;The Author(s) 2016 2016 International Society for Cerebral Blood Flow and Metabolism ;ISSN: 0271-678X ;EISSN: 1559-7016 ;DOI: 10.1177/0271678X16679420 ;PMID: 27837191

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  • Title:
    Age-associated physiological and pathological changes at the blood–brain barrier: A review
  • Author: Erdő, Franciska ; Denes, László ; de Lange, Elizabeth
  • Subjects: Aging - pathology ; Blood-Brain Barrier - chemistry ; Blood-Brain Barrier - metabolism ; Blood-Brain Barrier - pathology ; Humans ; Neurodegenerative Diseases - etiology ; Neurodegenerative Diseases - pathology ; Review
  • Is Part Of: Journal of Cerebral Blood Flow & Metabolism, 2017-01, Vol.37 (1), p.4-24
  • Description: The age-associated decline of the neurological and cognitive functions becomes more and more serious challenge for the developed countries with the increasing number of aged populations. The morphological and biochemical changes in the aging brain are the subjects of many extended research projects worldwide for a long time. However, the crucial role of the blood–brain barrier (BBB) impairment and disruption in the pathological processes in age-associated neurodegenerative disorders received special attention just for a few years. This article gives an overview on the major elements of the blood–brain barrier and its supporting mechanisms and also on their alterations during development, physiological aging process and age-associated neurodegenerative disorders (Alzheimer's disease, multiple sclerosis, Parkinson's disease, pharmacoresistant epilepsy). Besides the morphological alterations of the cellular elements (endothelial cells, astrocytes, pericytes, microglia, neuronal elements) of the BBB and neurovascular unit, the changes of the barrier at molecular level (tight junction proteins, adheres junction proteins, membrane transporters, basal lamina, extracellular matrix) are also summarized. The recognition of new players and initiators of the process of neurodegeneration at the level of the BBB may offer new avenues for novel therapeutic approaches for the treatment of numerous chronic neurodegenerative disorders currently without effective medication.
  • Publisher: London, England: SAGE Publications
  • Language: English
  • Identifier: ISSN: 0271-678X
    EISSN: 1559-7016
    DOI: 10.1177/0271678X16679420
    PMID: 27837191
  • Source: GFMER Free Medical Journals
    MEDLINE
    PubMed Central
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