Language:

An emerging role for BAG3 in gynaecological malignancies

British journal of cancer, 2021-09, Vol.125 (6), p.789-797 [Peer Reviewed Journal]

2021. The Author(s), under exclusive licence to Springer Nature Limited. ;The Author(s), under exclusive licence to Springer Nature Limited 2021. ;The Author(s), under exclusive licence to Springer Nature Limited 2021 ;ISSN: 0007-0920 ;EISSN: 1532-1827 ;DOI: 10.1038/s41416-021-01446-2 ;PMID: 34099896

Full text available

Citations Cited by

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
An emerging role for BAG3 in gynaecological malignancies
Author: De Marco, Margot ; Falco, Antonia ; Iaccarino, Roberta ; Raffone, Antonio ; Mollo, Antonio ; Guida, Maurizio ; Rosati, Alessandra ; Chetta, Massimiliano ; Genovese, Giovanni ; De Caro, Francesco ; Capunzo, Mario ; Turco, Maria Caterina ; Uversky, Vladimir N ; Marzullo, Liberato
Subjects: Adaptor Proteins, Signal Transducing - metabolism ; Apoptosis ; Apoptosis Regulatory Proteins - metabolism ; Autophagy ; Cell survival ; Cervical cancer ; Cervix ; Cytoskeleton ; Drug Resistance, Neoplasm ; Dysplasia ; Endometrium ; Female ; Gene Expression Regulation, Neoplastic ; Genital Neoplasms, Female - drug therapy ; Genital Neoplasms, Female - metabolism ; Genital Neoplasms, Female - pathology ; Gynecology ; Human papillomavirus ; Humans ; Neoplasm Grading ; Neoplasm Invasiveness ; Phagocytosis ; Review ; Survival Analysis ; Tumorigenesis ; Tumors ; Uterus
Is Part Of: British journal of cancer, 2021-09, Vol.125 (6), p.789-797
Description: BAG3, a member of the BAG family of co-chaperones, is a multidomain protein with a role in several cellular processes, including the control of apoptosis, autophagy and cytoskeletal dynamics. The expression of bag3 is negligible in most cells but can be induced by stress stimuli or malignant transformation. In some tumours, BAG3 has been reported to promote cell survival and resistance to therapy. The expression of BAG3 has been documented in ovarian, endometrial and cervical cancers, and studies have revealed biochemical and functional connections of BAG3 with proteins involved in the survival, invasion and resistance to therapy of these malignancies. BAG3 expression has also been shown to correlate with the grade of dysplasia in squamous intraepithelial lesions of the uterine cervix. Some aspects of BAG3 activity, such as its biochemical and functional interaction with the human papillomavirus proteins, could help in our understanding of the mechanisms of oncogenesis induced by the virus. This review aims to highlight the potential value of BAG3 studies in the field of gynaecological tumours.
Publisher: England: Nature Publishing Group
Language: English
Identifier: ISSN: 0007-0920
EISSN: 1532-1827
DOI: 10.1038/s41416-021-01446-2
PMID: 34099896
Source: Geneva Foundation Free Medical Journals at publisher websites
AUTh Library subscriptions: ProQuest Central
MEDLINE
PubMed Central

Back to results list


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

An emerging role for BAG3 in gynaecological malignancies

Searching Remote Databases, Please Wait