Language:

The value of daily platelet counts for predicting dengue shock syndrome: Results from a prospective observational study of 2301 Vietnamese children with dengue

PLoS neglected tropical diseases, 2017-04, Vol.11 (4), p.e0005498-e0005498 [Peer Reviewed Journal]

COPYRIGHT 2017 Public Library of Science ;COPYRIGHT 2017 Public Library of Science ;2017 Public Library of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Lam PK, Ngoc TV, Thu Thuy TT, Hong Van NT, Nhu Thuy TT, Hoai Tam DT, et al. (2017) The value of daily platelet counts for predicting dengue shock syndrome: Results from a prospective observational study of 2301 Vietnamese children with dengue. PLoS Negl Trop Dis 11(4): e0005498. https://doi.org/10.1371/journal.pntd.0005498 ;2017 Lam et al 2017 Lam et al ;2017 Public Library of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Lam PK, Ngoc TV, Thu Thuy TT, Hong Van NT, Nhu Thuy TT, Hoai Tam DT, et al. (2017) The value of daily platelet counts for predicting dengue shock syndrome: Results from a prospective observational study of 2301 Vietnamese children with dengue. PLoS Negl Trop Dis 11(4): e0005498. https://doi.org/10.1371/journal.pntd.0005498 ;ISSN: 1935-2735 ;ISSN: 1935-2727 ;EISSN: 1935-2735 ;DOI: 10.1371/journal.pntd.0005498 ;PMID: 28448490

Full text available

Citations Cited by

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
The value of daily platelet counts for predicting dengue shock syndrome: Results from a prospective observational study of 2301 Vietnamese children with dengue
Author: Lam, Phung Khanh ; Ngoc, Tran Van ; Thu Thuy, Truong Thi ; Hong Van, Nguyen Thi ; Nhu Thuy, Tran Thi ; Hoai Tam, Dong Thi ; Dung, Nguyen Minh ; Hanh Tien, Nguyen Thi ; Thanh Kieu, Nguyen Tan ; Simmons, Cameron ; Wills, Bridget ; Wolbers, Marcel
Messer, William B
Subjects: Adolescent ; Aggregation ; Aquatic insects ; Asian People ; Biology and Life Sciences ; Blood platelets ; Cardiovascular disease ; Child ; Child, Preschool ; Clinical medicine ; Dengue ; Dengue fever ; Dengue hemorrhagic fever ; Dengue virus ; Diagnosis ; Evaluation ; Female ; Generalized linear models ; Health risks ; Hematocrit ; Hospitals ; Humans ; Illnesses ; Infections ; Infectious diseases ; Intensive care ; Laboratories ; Male ; Medical prognosis ; Medicine ; Medicine and Health Sciences ; Mortality ; Mosquitoes ; Observational studies ; People and Places ; Physical Sciences ; Platelet aggregation test ; Platelet Count - methods ; Prediction models ; Prognosis ; Prospective Studies ; Public health ; Regression analysis ; Regression models ; Research and Analysis Methods ; Risk analysis ; Risk factors ; Severe Dengue - diagnosis ; Severe Dengue - pathology ; Signs and symptoms ; Statistical analysis ; Statistical models ; Studies ; Tropical diseases ; Vector-borne diseases ; Viral diseases ; Viral infections ; Vomiting
Is Part Of: PLoS neglected tropical diseases, 2017-04, Vol.11 (4), p.e0005498-e0005498
Description: Dengue is the most important mosquito-borne viral infection to affect humans. Although it usually manifests as a self-limited febrile illness, complications may occur as the fever subsides. A systemic vascular leak syndrome that sometimes progresses to life-threatening hypovolaemic shock is the most serious complication seen in children, typically accompanied by haemoconcentration and thrombocytopenia. Robust evidence on risk factors, especially features present early in the illness course, for progression to dengue shock syndrome (DSS) is lacking. Moreover, the potential value of incorporating serial haematocrit and platelet measurements in prediction models has never been assessed. We analyzed data from a prospective observational study of Vietnamese children aged 5-15 years admitted with clinically suspected dengue to the Hospital for Tropical Diseases in Ho Chi Minh City between 2001 and 2009. The analysis population comprised all children with laboratory-confirmed dengue enrolled between days 1-4 of illness. Logistic regression was the main statistical model for all univariate and multivariable analyses. The prognostic value of daily haematocrit levels and platelet counts were assessed using graphs and separate regression models fitted on each day of illness. Among the 2301 children included in the analysis, 143 (6%) progressed to DSS. Significant baseline risk factors for DSS included a history of vomiting, higher temperature, a palpable liver, and a lower platelet count. Prediction models that included serial daily platelet counts demonstrated better ability to discriminate patients who developed DSS from others, than models based on enrolment information only. However inclusion of daily haematocrit values did not improve prediction of DSS. Daily monitoring of platelet counts is important to help identify patients at high risk of DSS. Development of dynamic prediction models that incorporate signs, symptoms, and daily laboratory measurements, could improve DSS prediction and thereby reduce the burden on health services in endemic areas.
Publisher: United States: Public Library of Science
Language: English
Identifier: ISSN: 1935-2735
ISSN: 1935-2727
EISSN: 1935-2735
DOI: 10.1371/journal.pntd.0005498
PMID: 28448490
Source: TestCollectionTL3OpenAccess
GFMER Free Medical Journals
MEDLINE
PubMed Central
Public Library of Science (PLoS)
ProQuest Central

Back to results list


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

The value of daily platelet counts for predicting dengue shock syndrome: Results from a prospective observational study of 2301 Vietnamese children with dengue

Searching Remote Databases, Please Wait