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Is there a value for probiotic supplements in gestational diabetes mellitus? A randomized clinical trial

Journal of health, population and nutrition, 2015-11, Vol.33 (1), p.25-25, Article 25 [Peer Reviewed Journal]

COPYRIGHT 2015 BioMed Central Ltd. ;COPYRIGHT 2015 BioMed Central Ltd. ;Copyright BioMed Central 2015 ;Dolatkhah et al. 2015 ;ISSN: 2072-1315 ;ISSN: 1606-0997 ;EISSN: 2072-1315 ;DOI: 10.1186/s41043-015-0034-9 ;PMID: 26825666

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Title:
Is there a value for probiotic supplements in gestational diabetes mellitus? A randomized clinical trial
Author: Dolatkhah, Neda ; Hajifaraji, Majid ; Abbasalizadeh, Fatemeh ; Aghamohammadzadeh, Naser ; Mehrabi, Yadollah ; Abbasi, Mehran Mesgari
Subjects: Adult ; Analysis ; Anti-Obesity Agents - therapeutic use ; Bacteria ; Bifidobacterium animalis - growth & development ; Blood ; Blood Glucose - analysis ; Care and treatment ; Clinical research ; Clinical trials ; Diabetes ; Diabetes in pregnancy ; Diabetes mellitus ; Diabetes, Gestational - blood ; Diabetes, Gestational - diet therapy ; Diabetes, Gestational - metabolism ; Diagnosis ; Diet ; Diet, Diabetic ; Dietary supplements ; Double-Blind Method ; Fasting ; Female ; Food and nutrition ; Gestational diabetes mellitus ; Glucose ; Glucose metabolism ; Health aspects ; Humans ; Hyperglycemia - prevention & control ; Hypoglycemic Agents - therapeutic use ; Insulin ; Insulin Resistance ; Intervention ; Interventions ; Iran ; Lactobacillus acidophilus - growth & development ; Lactobacillus delbrueckii - growth & development ; Maternal Nutritional Physiological Phenomena ; Metabolism ; Newly diagnosed ; Pregnancy ; Pregnancy Trimester, Third ; Pregnant women ; Prevention ; Probiotics ; Probiotics - therapeutic use ; Public health ; Randomization ; Resistance ; Sensitivity ; Statistical analysis ; Streptococcus thermophilus - growth & development ; Sugar ; Therapeutic value ; Weight ; Weight Gain ; Young Adult
Is Part Of: Journal of health, population and nutrition, 2015-11, Vol.33 (1), p.25-25, Article 25
Description: Although several studies have found probiotics encouraging in prevention of gestational diabetes mellitus (GDM), the evidence for the use of probiotics in diagnosed GDM is largely limited. The aim of this study was to assess the effect of a probiotic supplement capsule containing four bacterial strains on glucose metabolism indices and weight changes in women with newly diagnosed GDM. Sixty-four pregnant women with GDM were enrolled into a double-blind placebo-controlled randomized clinical trial. They were randomly assigned to receive either a probiotic or placebo capsule along with dietary advice for eight consecutive weeks. The trend of weight gain along with glucose metabolism indices was assayed. During the first 6 weeks of the study, the weight gain trend was similar between the groups. However, in the last 2 weeks of the study, the weight gain in the probiotic group was significantly lower than in the placebo group (p < 0.05). Fasting blood sugar (FBS) decreased in both intervention (from 103.7 to 88.4 mg/dl) and control (from 100.9 to 93.6 mg/dl) groups significantly, and the decrease in the probiotic group was significantly higher than in the placebo group (p < 0.05). Insulin resistance index in the probiotic group had 6.74% reduction over the study period (p < 0.05). In the placebo group, however, there was an increase in insulin resistance index (6.45%), but the observed change in insulin resistance was not statistically significant. Insulin sensitivity index was increased in both groups. The post-intervention insulin sensitivity index in the probiotic group was not significantly different from placebo when adjusted for the baseline levels. The probiotic supplement appeared to affect glucose metabolism and weight gain among pregnant women with GDM. This needs to be confirmed in other settings before a therapeutic value could be approved.
Publisher: Bangladesh: BioMed Central Ltd
Language: English
Identifier: ISSN: 2072-1315
ISSN: 1606-0997
EISSN: 2072-1315
DOI: 10.1186/s41043-015-0034-9
PMID: 26825666
Source: GFMER Free Medical Journals
MEDLINE
PubMed Central
Bioline International
ProQuest Central
DOAJ Directory of Open Access Journals

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Is there a value for probiotic supplements in gestational diabetes mellitus? A randomized clinical trial

COPYRIGHT 2015 BioMed Central Ltd. ;COPYRIGHT 2015 BioMed Central Ltd. ;Copyright BioMed Central 2015 ;Dolatkhah et al. 2015 ;ISSN: 2072-1315 ;ISSN: 1606-0997 ;EISSN: 2072-1315 ;DOI: 10.1186/s41043-015-0034-9 ;PMID: 26825666

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