Language:

Effects of American ginseng (Panax quinquefolius) on neurocognitive function: an acute, randomised, double-blind, placebo-controlled, crossover study

Psychopharmacologia, 2010-10, Vol.212 (3), p.345-356 [Peer Reviewed Journal]

The Author(s) 2010 ;2015 INIST-CNRS ;Springer-Verlag 2010 ;ISSN: 0033-3158 ;EISSN: 1432-2072 ;DOI: 10.1007/s00213-010-1964-y ;PMID: 20676609 ;CODEN: PSYPAG

Full text available

Citations Cited by

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
Effects of American ginseng (Panax quinquefolius) on neurocognitive function: an acute, randomised, double-blind, placebo-controlled, crossover study
Author: Scholey, Andrew ; Ossoukhova, Anastasia ; Owen, Lauren ; Ibarra, Alvin ; Pipingas, Andrew ; He, Kan ; Roller, Marc ; Stough, Con
Subjects: Adolescent ; Adult ; Affect - drug effects ; Biological and medical sciences ; Biomedical and Life Sciences ; Biomedicine ; Blood Glucose - drug effects ; Cognition & reasoning ; Cognition - drug effects ; Cross-Over Studies ; Dose-Response Relationship, Drug ; Double-Blind Method ; Female ; Herbal medicine ; Humans ; Male ; Medical sciences ; Memory ; Memory, Short-Term - drug effects ; Neurology ; Neurosciences ; Original Investigation ; Panax - chemistry ; Panax ginseng ; Panax quinquefolius ; Pharmacology/Toxicology ; Plant Extracts - pharmacology ; Psychiatry ; Psychopharmacology ; Reaction Time - drug effects ; Time Factors ; Young Adult
Is Part Of: Psychopharmacologia, 2010-10, Vol.212 (3), p.345-356
Description: Rationale Over the last decade, Asian ginseng ( Panax ginseng ) has been shown to improve aspects of human cognitive function. American ginseng ( Panax quinquefolius ) has a distinct ginsenoside profile from P. ginseng , promising cognitive enhancing properties in preclinical studies and benefits processes linked to human cognition. Objectives The availability of a highly standardised extract of P. quinquefolius (Cereboost™) led us to evaluate its neurocognitive properties in humans for the first time. Methods This randomised, double-blind, placebo-controlled, crossover trial ( N = 32, healthy young adults) assessed the acute mood, neurocognitive and glycaemic effects of three doses (100, 200 400 mg) of Cereboost™ ( P. quinquefolius standardised to 10.65% ginsenosides). Participants' mood, cognitive function and blood glucose were measured 1, 3 and 6 h following administration. Results There was a significant improvement of working memory (WM) performance associated with P. quinquefolius. Corsi block performance was improved by all doses at all testing times. There were differential effects of all doses on other WM tasks which were maintained across the testing day. Choice reaction time accuracy and ‘calmness’ were significantly improved by 100 mg. There were no changes in blood glucose levels. Conclusions This preliminary study has identified robust working memory enhancement following administration of American ginseng . These effects are distinct from those of Asian ginseng and suggest that psychopharmacological properties depend critically on ginsenoside profiles. These results have ramifications for the psychopharmacology of herbal extracts and merit further study using different dosing regimens and in populations where cognition is fragile.
Publisher: Berlin/Heidelberg: Springer-Verlag
Language: English
Identifier: ISSN: 0033-3158
EISSN: 1432-2072
DOI: 10.1007/s00213-010-1964-y
PMID: 20676609
CODEN: PSYPAG
Source: ProQuest One Psychology
MEDLINE
Alma/SFX Local Collection
Springer OA刊
ProQuest Central

Back to results list


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

Effects of American ginseng (Panax quinquefolius) on neurocognitive function: an acute, randomised, double-blind, placebo-controlled, crossover study

The Author(s) 2010 ;2015 INIST-CNRS ;Springer-Verlag 2010 ;ISSN: 0033-3158 ;EISSN: 1432-2072 ;DOI: 10.1007/s00213-010-1964-y ;PMID: 20676609 ;CODEN: PSYPAG

Searching Remote Databases, Please Wait