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Left ventricle reverse remodeling in chronic aortic regurgitation patients with dilated ventricle after aortic valve replacement

Journal of cardiothoracic surgery, 2022-01, Vol.17 (1), p.8-8, Article 8 [Peer Reviewed Journal]

2022. The Author(s). ;COPYRIGHT 2022 BioMed Central Ltd. ;2022. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;The Author(s) 2022 ;ISSN: 1749-8090 ;EISSN: 1749-8090 ;DOI: 10.1186/s13019-022-01754-5 ;PMID: 35034651

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Title:
Left ventricle reverse remodeling in chronic aortic regurgitation patients with dilated ventricle after aortic valve replacement
Author: Zhang, Ming-Kui ; Li, Li-Na ; Xue, Hui ; Tang, Xiu-Jie ; Sun, He ; Wu, Qing-Yu
Subjects: Analysis ; Aorta ; Aortic valve ; Aortic Valve - diagnostic imaging ; Aortic Valve - surgery ; Aortic valve insufficiency ; Aortic Valve Insufficiency - complications ; Aortic Valve Insufficiency - diagnostic imaging ; Aortic Valve Insufficiency - surgery ; Aortic valve regurgitation ; Aortic valve replacement ; Asymptomatic ; Cardiac arrhythmia ; Cardiology ; Ejection fraction ; Follow up ; Heart ; Heart failure ; Heart Valve Prosthesis Implantation ; Heart valves ; Heart Ventricles - diagnostic imaging ; Heart Ventricles - surgery ; Hospitalization ; Humans ; Left ventricle remodeling ; Patients ; Regurgitation ; Retrospective Studies ; Statistical analysis ; Stroke Volume ; Thoracic surgery ; Variables ; Ventricle ; Ventricular Function, Left ; Ventricular Remodeling
Is Part Of: Journal of cardiothoracic surgery, 2022-01, Vol.17 (1), p.8-8, Article 8
Description: Aortic valve replacement (AVR) for chronic aortic regurgitation (AR) with a severe dilated left ventricle and dysfunction leads to left ventricle remodeling. But there are rarely reports on the left ventricle reverse remodeling (LVRR) after AVR. This study aimed to investigate the LVRR and outcomes in chronic AR patients with severe dilated left ventricle and dysfunction after AVR. We retrospectively analyzed the clinical datum of chronic aortic regurgitation patients who underwent isolated AVR. The LVRR was defined as an increase in left ventricular ejection fraction (LVEF) at least 10 points or a follow-up LVEF ≥ 50%, and a decrease in the indexed left ventricular end-diastolic diameter of at least 10%, or an indexed left ventricular end-diastolic diameter ≤ 33 mm/m . The changes in echocardiographic parameters after AVR, survival analysis, the predictors of major adverse cardiac events (MACE), the association between LVRR and MACE were analyzed. Sixty-nine patients with severe dilated left ventricle and dysfunction underwent isolated AVR. LV remodeling in 54 patients and no LV remodeling in 15 patients at 6-12 months follow-up. The preoperative left ventricular dimensions and volumes were larger, and the EF was lower in the LV no remodeling group than those in the LV remodeling group (all p < 0.05). The adverse LVRR was the predictor for MACE at follow-up. The mean follow-up period was 47.29 months (range 6 to 173 months). The rate of freedom from MACE was 94.44% at 5 years and 92.59% at 10 years in the remodeling group, 60% at 5 years, and 46.67% at 10 years in the no remodeling group. The left ventricle remodeling after AVR was the important predictor for MACE. LV no remodeling may not be associated with benefits from AVR for chronic aortic regurgitation patients with severe dilated LV and dysfunction.
Publisher: England: BioMed Central Ltd
Language: English
Identifier: ISSN: 1749-8090
EISSN: 1749-8090
DOI: 10.1186/s13019-022-01754-5
PMID: 35034651
Source: SpringerOpen
GFMER Free Medical Journals
MEDLINE
PubMed Central
ROAD: Directory of Open Access Scholarly Resources
ProQuest Central
DOAJ Directory of Open Access Journals

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Left ventricle reverse remodeling in chronic aortic regurgitation patients with dilated ventricle after aortic valve replacement

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