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14-3-3 proteins are required for hippocampal long-term potentiation and associative learning and memory

The Journal of neuroscience, 2014-04, Vol.34 (14), p.4801-4808 [Peer Reviewed Journal]

Copyright © 2014 the authors 0270-6474/14/344801-08$15.00/0 2014 ;ISSN: 0270-6474 ;EISSN: 1529-2401 ;DOI: 10.1523/jneurosci.4393-13.2014 ;PMID: 24695700

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Title:
14-3-3 proteins are required for hippocampal long-term potentiation and associative learning and memory
Author: Qiao, Haifa ; Foote, Molly ; Graham, Kourtney ; Wu, Yuying ; Zhou, Yi
Subjects: 14-3-3 Proteins - deficiency ; 14-3-3 Proteins - physiology ; Animals ; Association Learning - physiology ; Avoidance Learning - physiology ; Bacterial Proteins - genetics ; Bacterial Proteins - metabolism ; Conditioning (Psychology) - physiology ; Electric Stimulation ; Excitatory Postsynaptic Potentials - genetics ; Fear - physiology ; Hippocampus - metabolism ; Hippocampus - physiology ; In Vitro Techniques ; Long-Term Potentiation - genetics ; Long-Term Potentiation - physiology ; Luminescent Proteins - genetics ; Luminescent Proteins - metabolism ; Memory - physiology ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Patch-Clamp Techniques
Is Part Of: The Journal of neuroscience, 2014-04, Vol.34 (14), p.4801-4808
Description: 14-3-3 is a family of regulatory proteins highly expressed in the brain. Previous invertebrate studies have demonstrated the importance of 14-3-3 in the regulation of synaptic functions and learning and memory. However, the in vivo role of 14-3-3 in these processes has not been determined using mammalian animal models. Here, we report the behavioral and electrophysiological characterization of a new animal model of 14-3-3 proteins. These transgenic mice, considered to be a 14-3-3 functional knock-out, express a known 14-3-3 inhibitor in various brain regions of different founder lines. We identify a founder-specific impairment in hippocampal-dependent learning and memory tasks, as well as a correlated suppression in long-term synaptic plasticity of the hippocampal synapses. Moreover, hippocampal synaptic NMDA receptor levels are selectively reduced in the transgenic founder line that exhibits both behavioral and synaptic plasticity deficits. Collectively, our findings provide evidence that 14-3-3 is a positive regulator of associative learning and memory at both the behavioral and cellular level.
Publisher: United States: Society for Neuroscience
Language: English
Identifier: ISSN: 0270-6474
EISSN: 1529-2401
DOI: 10.1523/jneurosci.4393-13.2014
PMID: 24695700
Source: GFMER Free Medical Journals
MEDLINE
PubMed Central
Alma/SFX Local Collection

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14-3-3 proteins are required for hippocampal long-term potentiation and associative learning and memory

Copyright © 2014 the authors 0270-6474/14/344801-08$15.00/0 2014 ;ISSN: 0270-6474 ;EISSN: 1529-2401 ;DOI: 10.1523/jneurosci.4393-13.2014 ;PMID: 24695700

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