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Implication of high risk human papillomavirus HR-HPV infection in prostate cancer in Indian population--a pioneering case-control analysis

Scientific reports, 2015-01, Vol.5 (1), p.7822-7822, Article 7822 [Peer Reviewed Journal]

Copyright Nature Publishing Group Jan 2015 ;Copyright © 2015, Macmillan Publishers Limited. All rights reserved 2015 Macmillan Publishers Limited. All rights reserved ;ISSN: 2045-2322 ;EISSN: 2045-2322 ;DOI: 10.1038/srep07822 ;PMID: 25592643

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Title:
Implication of high risk human papillomavirus HR-HPV infection in prostate cancer in Indian population--a pioneering case-control analysis
Author: Singh, Neha ; Hussain, Showket ; Kakkar, Nandita ; Singh, Shrawan K ; Sobti, Ranbir C ; Bharadwaj, Mausumi
Subjects: Aged ; Case-Control Studies ; Conserved sequence ; DNA, Viral - analysis ; Health risk assessment ; HPV infection ; Human papillomavirus ; Human papillomavirus 16 - genetics ; Human papillomavirus 16 - isolation & purification ; Human papillomavirus 18 - genetics ; Human papillomavirus 18 - isolation & purification ; Humans ; Incidence ; India - epidemiology ; Infections ; Male ; Medical sciences ; Medicin ; Middle Aged ; Neoplasm Staging ; Papillomaviridae - genetics ; Papillomaviridae - isolation & purification ; Papillomavirus Infections - complications ; Papillomavirus Infections - epidemiology ; Papillomavirus Infections - virology ; Polymerase Chain Reaction ; Primers ; Prostate ; Prostate - pathology ; Prostate - virology ; Prostate cancer ; Prostatic Neoplasms - complications ; Prostatic Neoplasms - pathology ; Risk ; Serotyping ; Typing ; Viral oncology
Is Part Of: Scientific reports, 2015-01, Vol.5 (1), p.7822-7822, Article 7822
Description: Prostate cancer is the second most common cancer with sexual history as a consistent risk factor. This is the pioneering study that evaluates the frequency of HPV infection in prostate cancer in India. Ninety five (95) histopathologically confirmed cancer and fifty five (55) BPH from Indian population were analyzed for HPV infection using a pair of consensus sequence primer followed by type specific PCRs for both high-risk and low-risk HPV types. The data demonstrate HPV infection in 41% of prostate tumor biopsies and 20% in BPH. Subsequent PCR- based HPV typing using type - specific primers revealed 32% were infected with HPV type 16 whereas 6% were found to be positive for HPV type 18, while in BPH controls only 5% of the BPH controls were infected with HPV 16 and this difference was highly significant (p = 0.0004). Significant proportion of HPV infected (74%) cases belonged to stage III and IV (p < 0.001) with a high Gleason score ≥ 8 (p = 0.003). The study represents for the first time the incidence of HPV infection in prostate cancer in Indian population and strengthens the hypothesis that HPV infection could be one of the co factor associated with progression of prostate cancer.
Publisher: England: Nature Publishing Group
Language: English
Identifier: ISSN: 2045-2322
EISSN: 2045-2322
DOI: 10.1038/srep07822
PMID: 25592643
Source: Open Access: PubMed Central
AUTh Library subscriptions: ProQuest Central
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Implication of high risk human papillomavirus HR-HPV infection in prostate cancer in Indian population--a pioneering case-control analysis

Copyright Nature Publishing Group Jan 2015 ;Copyright © 2015, Macmillan Publishers Limited. All rights reserved 2015 Macmillan Publishers Limited. All rights reserved ;ISSN: 2045-2322 ;EISSN: 2045-2322 ;DOI: 10.1038/srep07822 ;PMID: 25592643

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