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REAC technology and hyaluron synthase 2, an interesting network to slow down stem cell senescence

Scientific reports, 2016-06, Vol.6 (1), p.28682-28682, Article 28682 [Peer Reviewed Journal]

Copyright Nature Publishing Group Jun 2016 ;Copyright © 2016, Macmillan Publishers Limited 2016 Macmillan Publishers Limited ;ISSN: 2045-2322 ;EISSN: 2045-2322 ;DOI: 10.1038/srep28682 ;PMID: 27339908

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Title:
REAC technology and hyaluron synthase 2, an interesting network to slow down stem cell senescence
Author: Maioli, Margherita ; Rinaldi, Salvatore ; Pigliaru, Gianfranco ; Santaniello, Sara ; Basoli, Valentina ; Castagna, Alessandro ; Fontani, Vania ; Ventura, Carlo
Subjects: Adipose Tissue - metabolism ; Cell Differentiation ; Cellular Senescence ; Electric Stimulation ; Electricity ; Fibroblasts - metabolism ; Gene Expression Regulation ; Humans ; Hyaluronan Receptors - metabolism ; Hyaluronan Synthases - metabolism ; Hyaluronic Acid - chemistry ; Hymecromone - pharmacology ; Nanog Homeobox Protein - metabolism ; Nitric Oxide Synthase - metabolism ; Octamer Transcription Factor-3 - metabolism ; Polycomb Repressive Complex 1 - metabolism ; Radio Waves ; SOXB1 Transcription Factors - metabolism ; Stem Cells - cytology ; Telomerase - metabolism
Is Part Of: Scientific reports, 2016-06, Vol.6 (1), p.28682-28682, Article 28682
Description: Hyaluronic acid (HA) plays a fundamental role in cell polarity and hydrodynamic processes, affording significant modulation of proliferation, migration, morphogenesis and senescence, with deep implication in the ability of stem cells to execute their differentiating plans. The Radio Electric Asymmetric Conveyer (REAC) technology is aimed to optimize the ions fluxes at the molecular level in order to optimize the molecular mechanisms driving cellular asymmetry and polarization. Here, we show that treatment with 4-methylumbelliferone (4-MU), a potent repressor of type 2 HA synthase and endogenous HA synthesis, dramatically antagonized the ability of REAC to recover the gene and protein expression of Bmi1, Oct4, Sox2, and Nanog in ADhMSCs that had been made senescent by prolonged culture up to the 30(th) passage. In senescent ADhMSCs, 4-MU also counteracted the REAC ability to rescue the gene expression of TERT, and the associated resumption of telomerase activity. Hence, the anti-senescence action of REAC is largely dependent upon the availability of endogenous HA synthesis. Endogenous HA and HA-binding proteins with REAC technology create an interesting network that acts on the modulation of cell polarity and intracellular environment. This suggests that REAC technology is effective on an intracellular niche level of stem cell regulation.
Publisher: England: Nature Publishing Group
Language: English
Identifier: ISSN: 2045-2322
EISSN: 2045-2322
DOI: 10.1038/srep28682
PMID: 27339908
Source: MEDLINE
PubMed Central
ProQuest Central
DOAJ Directory of Open Access Journals

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REAC technology and hyaluron synthase 2, an interesting network to slow down stem cell senescence

Copyright Nature Publishing Group Jun 2016 ;Copyright © 2016, Macmillan Publishers Limited 2016 Macmillan Publishers Limited ;ISSN: 2045-2322 ;EISSN: 2045-2322 ;DOI: 10.1038/srep28682 ;PMID: 27339908

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