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Far-UVC light (222 nm) efficiently and safely inactivates airborne human coronaviruses

Scientific reports, 2020-06, Vol.10 (1), p.10285-8, Article 10285 [Peer Reviewed Journal]

The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;The Author(s) 2020. corrected publication 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;The Author(s) 2020, corrected publication 2021 ;ISSN: 2045-2322 ;EISSN: 2045-2322 ;DOI: 10.1038/s41598-020-67211-2 ;PMID: 32581288

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Title:
Far-UVC light (222 nm) efficiently and safely inactivates airborne human coronaviruses
Author: Buonanno, Manuela ; Welch, David ; Shuryak, Igor ; Brenner, David J
Subjects: Antiviral Agents - adverse effects ; Betacoronavirus - radiation effects ; Cell Line ; Coronaviridae ; Coronavirus 229E, Human - radiation effects ; Coronavirus Infections - radiotherapy ; Coronavirus OC43, Human - radiation effects ; Coronaviruses ; COVID-19 ; Disinfection - methods ; Humans ; Influenza ; Pandemics ; Particulate Matter - radiation effects ; Pneumonia, Viral - radiotherapy ; SARS Virus - radiation effects ; SARS-CoV-2 ; Severe acute respiratory syndrome coronavirus 2 ; Ultraviolet radiation ; Ultraviolet Rays - adverse effects ; Virus Inactivation - radiation effects
Is Part Of: Scientific reports, 2020-06, Vol.10 (1), p.10285-8, Article 10285
Description: A direct approach to limit airborne viral transmissions is to inactivate them within a short time of their production. Germicidal ultraviolet light, typically at 254 nm, is effective in this context but, used directly, can be a health hazard to skin and eyes. By contrast, far-UVC light (207-222 nm) efficiently kills pathogens potentially without harm to exposed human tissues. We previously demonstrated that 222-nm far-UVC light efficiently kills airborne influenza virus and we extend those studies to explore far-UVC efficacy against airborne human coronaviruses alpha HCoV-229E and beta HCoV-OC43. Low doses of 1.7 and 1.2 mJ/cm inactivated 99.9% of aerosolized coronavirus 229E and OC43, respectively. As all human coronaviruses have similar genomic sizes, far-UVC light would be expected to show similar inactivation efficiency against other human coronaviruses including SARS-CoV-2. Based on the beta-HCoV-OC43 results, continuous far-UVC exposure in occupied public locations at the current regulatory exposure limit (~3 mJ/cm /hour) would result in ~90% viral inactivation in ~8 minutes, 95% in ~11 minutes, 99% in ~16 minutes and 99.9% inactivation in ~25 minutes. Thus while staying within current regulatory dose limits, low-dose-rate far-UVC exposure can potentially safely provide a major reduction in the ambient level of airborne coronaviruses in occupied public locations.
Publisher: England: Nature Publishing Group
Language: English
Identifier: ISSN: 2045-2322
EISSN: 2045-2322
DOI: 10.1038/s41598-020-67211-2
PMID: 32581288
Source: DOAJ : Directory of Open Access Journals
Open Access: PubMed Central
AUTh Library subscriptions: ProQuest Central
MEDLINE
Coronavirus Research Database

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Far-UVC light (222 nm) efficiently and safely inactivates airborne human coronaviruses

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