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Plasma proteomic biomarker signature of age predicts health and life span

eLife, 2020-11, Vol.9 [Peer Reviewed Journal]

ISSN: 2050-084X ;EISSN: 2050-084X ;DOI: 10.7554/eLife.61073 ;PMID: 33210602

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Title:
Plasma proteomic biomarker signature of age predicts health and life span
Author: Tanaka, Toshiko ; Basisty, Nathan ; Fantoni, Giovanna ; Candia, Julián ; Moore, Ann Z ; Biancotto, Angelique ; Schilling, Birgit ; Bandinelli, Stefania ; Ferrucci, Luigi
Subjects: Adult ; Aged ; Aged, 80 and over ; aging ; Aging - blood ; Aging - physiology ; biomarker ; Biomarkers - blood ; Blood Proteins - physiology ; Computational and Systems Biology ; Epidemiology and Global Health ; Female ; healthspan ; Humans ; Male ; Middle Aged ; Proteomics ; Risk Factors ; Young Adult
Is Part Of: eLife, 2020-11, Vol.9
Description: Older age is a strong shared risk factor for many chronic diseases, and there is increasing interest in identifying aging biomarkers. Here, a proteomic analysis of 1301 plasma proteins was conducted in 997 individuals between 21 and 102 years of age. We identified 651 proteins associated with age (506 over-represented, 145 underrepresented with age). Mediation analysis suggested a role for partial -epigenetic control of protein expression with age. Of the age-associated proteins, 33.5% and 45.3%, were associated with mortality and multimorbidity, respectively. There was enrichment of proteins associated with inflammation and extracellular matrix as well as senescence-associated secretory proteins. A 76-protein proteomic age signature predicted accumulation of chronic diseases and all-cause mortality. These data support the use of proteomic biomarkers to monitor aging trajectories and to identify individuals at higher risk of disease to be targeted for in depth diagnostic procedures and early interventions.
Publisher: England: eLife Sciences Publications, Ltd
Language: English
Identifier: ISSN: 2050-084X
EISSN: 2050-084X
DOI: 10.7554/eLife.61073
PMID: 33210602
Source: MEDLINE
PubMed Central
ROAD: Directory of Open Access Scholarly Resources
ProQuest Central
DOAJ Directory of Open Access Journals

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Plasma proteomic biomarker signature of age predicts health and life span

ISSN: 2050-084X ;EISSN: 2050-084X ;DOI: 10.7554/eLife.61073 ;PMID: 33210602

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