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Arrhythmia burden in adults with surgically repaired tetralogy of Fallot: a multi-institutional study

Circulation (New York, N.Y.), 2010-08, Vol.122 (9), p.868-875 [Peer Reviewed Journal]

ISSN: 0009-7322 ;EISSN: 1524-4539 ;DOI: 10.1161/CIRCULATIONAHA.109.928481 ;PMID: 20713900

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Title:
Arrhythmia burden in adults with surgically repaired tetralogy of Fallot: a multi-institutional study
Author: Khairy, Paul ; Aboulhosn, Jamil ; Gurvitz, Michelle Z ; Opotowsky, Alexander R ; Mongeon, François-Pierre ; Kay, Joseph ; Valente, Anne Marie ; Earing, Michael G ; Lui, George ; Gersony, Deborah R ; Cook, Stephen ; Ting, Jennifer Grando ; Nickolaus, Michelle J ; Webb, Gary ; Landzberg, Michael J ; Broberg, Craig S
Subjects: Adult ; Arrhythmias, Cardiac - epidemiology ; Arrhythmias, Cardiac - therapy ; Atrial Fibrillation - epidemiology ; Atrial Fibrillation - therapy ; Atrial Flutter - epidemiology ; Atrial Flutter - therapy ; Cross-Sectional Studies ; Female ; Humans ; Male ; Middle Aged ; Multivariate Analysis ; Pacemaker, Artificial - statistics & numerical data ; Prevalence ; Pulmonary Atresia - epidemiology ; Retrospective Studies ; Risk Factors ; Tachycardia, Atrioventricular Nodal Reentry - epidemiology ; Tachycardia, Atrioventricular Nodal Reentry - therapy ; Tachycardia, Ventricular - epidemiology ; Tachycardia, Ventricular - therapy ; Tetralogy of Fallot - epidemiology ; Tetralogy of Fallot - surgery ; Young Adult
Is Part Of: Circulation (New York, N.Y.), 2010-08, Vol.122 (9), p.868-875
Description: The arrhythmia burden in tetralogy of Fallot, types of arrhythmias encountered, and risk profile may change as the population ages. The Alliance for Adult Research in Congenital Cardiology (AARCC) conducted a multicenter cross-sectional study to quantify the arrhythmia burden in tetralogy of Fallot, to characterize age-related trends, and to identify associated factors. A total of 556 patients, 54.0% female, 36.8+/-12.0 years of age were recruited from 11 centers. Overall, 43.3% had a sustained arrhythmia or arrhythmia intervention. Prevalence of atrial tachyarrhythmias was 20.1%. Factors associated with intraatrial reentrant tachycardia in multivariable analyses were right atrial enlargement (odds ratio [OR], 6.2; 95% confidence interval [CI], 2.8 to 13.6), hypertension (OR, 2.3; 95% CI, 1.1 to 4.6), and number of cardiac surgeries (OR, 1.4; 95% CI, 1.2 to 1.6). Older age (OR, 1.09 per year; 95% CI, 1.05 to 1.12), lower left ventricular ejection fraction (OR, 0.93 per unit; 95% CI, 0.89 to 0.96), left atrial dilation (OR, 3.2; 95% CI, 1.5 to 6.8), and number of cardiac surgeries (OR, 1.5; 95% CI, 1.2 to 1.9) were jointly associated with atrial fibrillation. Ventricular arrhythmias were prevalent in 14.6% and jointly associated with number of cardiac surgeries (OR, 1.3; 95% CI, 1.1 to 1.6), QRS duration (OR, 1.02 per 1 ms; 95% CI, 1.01 to 1.03), and left ventricular diastolic dysfunction (OR, 3.3; 95% CI, 1.5 to 7.1). Prevalence of atrial fibrillation and ventricular arrhythmias markedly increased after 45 years of age. The arrhythmia burden in adults with tetralogy of Fallot is considerable, with various subtypes characterized by different profiles. Atrial fibrillation and ventricular arrhythmias appear to be influenced more by left- than right-sided heart disease.
Publisher: United States
Language: English
Identifier: ISSN: 0009-7322
EISSN: 1524-4539
DOI: 10.1161/CIRCULATIONAHA.109.928481
PMID: 20713900
Source: GFMER Free Medical Journals
MEDLINE

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Arrhythmia burden in adults with surgically repaired tetralogy of Fallot: a multi-institutional study

ISSN: 0009-7322 ;EISSN: 1524-4539 ;DOI: 10.1161/CIRCULATIONAHA.109.928481 ;PMID: 20713900

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