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Dilated Cardiomyopathy: Genetic Determinants and Mechanisms
Circulation research, 2017-09, Vol.121 (7), p.731-748
[Peer Reviewed Journal]
2017 American Heart Association, Inc. ;ISSN: 0009-7330 ;EISSN: 1524-4571 ;DOI: 10.1161/CIRCRESAHA.116.309396 ;PMID: 28912180
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Title:
Dilated Cardiomyopathy: Genetic Determinants and Mechanisms
Author:
McNally, Elizabeth M
;
Mestroni, Luisa
Subjects:
Animals
;
Biopsy
;
Cardiac Imaging Techniques
;
Cardiomyopathy, Dilated - genetics
;
Cardiomyopathy, Dilated - pathology
;
Cardiomyopathy, Dilated - physiopathology
;
Cardiomyopathy, Dilated - therapy
;
DNA Mutational Analysis
;
Genetic Markers
;
Genetic Predisposition to Disease
;
Humans
;
Molecular Diagnostic Techniques
;
Mutation
;
Myocardium - pathology
;
Phenotype
;
Predictive Value of Tests
;
Prognosis
;
Risk Assessment
;
Risk Factors
;
Ventricular Function
Is Part Of:
Circulation research, 2017-09, Vol.121 (7), p.731-748
Description:
Nonischemic dilated cardiomyopathy (DCM) often has a genetic pathogenesis. Because of the large number of genes and alleles attributed to DCM, comprehensive genetic testing encompasses ever-increasing gene panels. Genetic diagnosis can help predict prognosis, especially with regard to arrhythmia risk for certain subtypes. Moreover, cascade genetic testing in family members can identify those who are at risk or with early stage disease, offering the opportunity for early intervention. This review will address diagnosis and management of DCM, including the role of genetic evaluation. We will also overview distinct genetic pathways linked to DCM and their pathogenetic mechanisms. Historically, cardiac morphology has been used to classify cardiomyopathy subtypes. Determining genetic variants is emerging as an additional adjunct to help further refine subtypes of DCM, especially where arrhythmia risk is increased, and ultimately contribute to clinical management.
Publisher:
United States: American Heart Association, Inc
Language:
English
Identifier:
ISSN: 0009-7330
EISSN: 1524-4571
DOI: 10.1161/CIRCRESAHA.116.309396
PMID: 28912180
Source:
GFMER Free Medical Journals
MEDLINE
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