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N-terminal pro-brain natriuretic peptide and cardiovascular or all-cause mortality in the general population: A meta-analysis

Scientific reports, 2017-01, Vol.7 (1), p.41504-41504, Article 41504 [Peer Reviewed Journal]

Copyright Nature Publishing Group Jan 2017 ;Copyright © 2017, The Author(s) 2017 The Author(s) ;ISSN: 2045-2322 ;EISSN: 2045-2322 ;DOI: 10.1038/srep41504 ;PMID: 28134294

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Title:
N-terminal pro-brain natriuretic peptide and cardiovascular or all-cause mortality in the general population: A meta-analysis
Author: Geng, Zhaohua ; Huang, Lan ; Song, Mingbao ; Song, Yaoming
Subjects: Beta blockers ; Biomarkers ; Brain natriuretic peptide ; Cardiovascular disease ; Cardiovascular diseases ; Cardiovascular Diseases - blood ; Cardiovascular Diseases - epidemiology ; Cardiovascular Diseases - mortality ; Cause of Death ; Coronary artery disease ; Coronary Disease - blood ; Coronary Disease - epidemiology ; Coronary Disease - mortality ; Female ; Follow-Up Studies ; Health risk assessment ; Heart diseases ; Humans ; Male ; Mortality ; Natriuretic Peptide, Brain - blood ; Peptide Fragments - blood ; Population ; Population Surveillance ; Proportional Hazards Models ; Studies
Is Part Of: Scientific reports, 2017-01, Vol.7 (1), p.41504-41504, Article 41504
Description: The prognostic role of N-terminal pro-brain natriuretic peptide (NT-proBNP) in the general population remains controversial. We conducted this meta-analysis to investigate the association between baseline NT-proBNP concentrations and cardiovascular or all-cause mortality in the general population. PubMed and Embase databases were systematically searched from their inception to August 2016. Prospective observational studies that investigated the association between baseline NT-proBNP concentrations and cardiovascular or all-cause mortality in the general population were eligible. A summary of the hazard ratio (HR) and 95% confidence interval (CI) of mortality were calculated by the highest versus the lowest category of NT-proBNP concentrations. Eleven studies with a total of 25,715 individuals were included. Compared individuals in the highest with those in the lowest category of NT-proBNP, the pooled HR was 2.44 (95% CI 2.11-2.83) for all-cause mortality, 3.77 (95% CI 2.85-5.00) for cardiovascular mortality, and 2.35 (95% CI 1.45-3.82) for coronary heart disease mortality, respectively. Subgroup analyses indicated that the effects of NT-proBNP on the risk of cardiovascular mortality (RR 2.27) and all-cause mortality (RR 3.00) appeared to be slightly lower among men. Elevated NT-proBNP concentrations appeared to be independently associated with increased risk of cardiovascular and all-cause mortality in the general population.
Publisher: England: Nature Publishing Group
Language: English
Identifier: ISSN: 2045-2322
EISSN: 2045-2322
DOI: 10.1038/srep41504
PMID: 28134294
Source: MEDLINE
PubMed Central
ProQuest Central
DOAJ Directory of Open Access Journals

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N-terminal pro-brain natriuretic peptide and cardiovascular or all-cause mortality in the general population: A meta-analysis

Copyright Nature Publishing Group Jan 2017 ;Copyright © 2017, The Author(s) 2017 The Author(s) ;ISSN: 2045-2322 ;EISSN: 2045-2322 ;DOI: 10.1038/srep41504 ;PMID: 28134294

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