Language:

CDD: NCBI's conserved domain database

Nucleic acids research, 2015-01, Vol.43 (Database issue), p.D222-D226 [Peer Reviewed Journal]

Published by Oxford University Press on behalf of Nucleic Acids Research 2014. This work is written by US Government employees and is in the public domain in the US. ;Published by Oxford University Press on behalf of Nucleic Acids Research 2014. This work is written by US Government employees and is in the public domain in the US. 2015 ;ISSN: 0305-1048 ;EISSN: 1362-4962 ;DOI: 10.1093/nar/gku1221 ;PMID: 25414356

Full text available

Citations Cited by

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
CDD: NCBI's conserved domain database
Author: Marchler-Bauer, Aron ; Derbyshire, Myra K ; Gonzales, Noreen R ; Lu, Shennan ; Chitsaz, Farideh ; Geer, Lewis Y ; Geer, Renata C ; He, Jane ; Gwadz, Marc ; Hurwitz, David I ; Lanczycki, Christopher J ; Lu, Fu ; Marchler, Gabriele H ; Song, James S ; Thanki, Narmada ; Wang, Zhouxi ; Yamashita, Roxanne A ; Zhang, Dachuan ; Zheng, Chanjuan ; Bryant, Stephen H
Subjects: Amino Acid Motifs ; Amino Acid Sequence ; Conserved Sequence ; Data Curation ; Database Issue ; Databases, Protein ; Protein Structure, Tertiary
Is Part Of: Nucleic acids research, 2015-01, Vol.43 (Database issue), p.D222-D226
Description: NCBI's CDD, the Conserved Domain Database, enters its 15(th) year as a public resource for the annotation of proteins with the location of conserved domain footprints. Going forward, we strive to improve the coverage and consistency of domain annotation provided by CDD. We maintain a live search system as well as an archive of pre-computed domain annotation for sequences tracked in NCBI's Entrez protein database, which can be retrieved for single sequences or in bulk. We also maintain import procedures so that CDD contains domain models and domain definitions provided by several collections available in the public domain, as well as those produced by an in-house curation effort. The curation effort aims at increasing coverage and providing finer-grained classifications of common protein domains, for which a wealth of functional and structural data has become available. CDD curation generates alignment models of representative sequence fragments, which are in agreement with domain boundaries as observed in protein 3D structure, and which model the structurally conserved cores of domain families as well as annotate conserved features. CDD can be accessed at http://www.ncbi.nlm.nih.gov/Structure/cdd/cdd.shtml.
Publisher: England: Oxford University Press
Language: English
Identifier: ISSN: 0305-1048
EISSN: 1362-4962
DOI: 10.1093/nar/gku1221
PMID: 25414356
Source: Geneva Foundation Free Medical Journals at publisher websites
Oxford University Press Open Access
MEDLINE
PubMed Central
Directory of Open Access Journals

Back to results list


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

CDD: NCBI's conserved domain database

Searching Remote Databases, Please Wait