skip to main content
Language:
Search Limited to: Search Limited to: Resource type Show Results with: Show Results with: Search type Index

Impacts of Age and Gender on Brain Edema in a Mouse Water Intoxication Model

Acta medica Okayama, 2024-04, Vol.78 (2), p.115-122 [Peer Reviewed Journal]

ISSN: 0386-300X ;DOI: 10.18926/AMO/66914 ;PMID: 38688829

Full text available

Citations Cited by
  • Title:
    Impacts of Age and Gender on Brain Edema in a Mouse Water Intoxication Model
  • Author: Nakamura-Maruyama, Emi ; Irie, Keiichiro ; Narita, Kazuhiko ; Himi, Naoyuki ; Miyamoto, Osamu ; Nakamura, Takehiro
  • Subjects: Age Factors ; Animals ; Aquaporin 4 - genetics ; Brain - metabolism ; Brain - pathology ; Brain Edema - pathology ; Caspase 3 - metabolism ; Disease Models, Animal ; Female ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Sex Factors ; Water Intoxication - complications
  • Is Part Of: Acta medica Okayama, 2024-04, Vol.78 (2), p.115-122
  • Description: Brain edema causes abnormal fluid retention and can be fatal in severe cases. Although it develops in various diseases, most treatments for brain edema are classical. We analyzed the impacts of age and gender on the characteristics of a water intoxication model that induces pure brain edema in mice and examined the model's usefulness for research regarding new treatments for brain edema. C57BL/6J mice received an intraperitoneal administration of 10% body weight distilled water, and we calculated the brain water content by measuring the brain-tissue weight immediately after dissection and after drying. We analyzed 8-OHdG and caspase-3 values to investigate the brain damage. We also applied this model in aquaporin 4 knockout (AQP4-) mice and compared these mice with wild-type mice. The changes in water content differed by age and gender, and the 8-OHdG and caspase-3 values differed by age. Suppression of brain edema by AQP4- was also confirmed. These results clarified the differences in the onset of brain edema by age and gender, highlighting the importance of considering the age and gender of model animals. Similar studies using genetically modified mice are also possible. Our findings indicate that this water intoxication model is effective for explorations of new brain edema treatments.
  • Publisher: Japan
  • Language: English
  • Identifier: ISSN: 0386-300X
    DOI: 10.18926/AMO/66914
    PMID: 38688829
  • Source: Geneva Foundation Free Medical Journals at publisher websites
    MEDLINE
    Alma/SFX Local Collection
Back to results list
INSPIRE LIBRARY - TON DUC THANG UNIVERSITY (84-028) 37 755 057 Feedback
19 Nguyen Huu Tho St. Dist.7, HCM thuvien@tdtu.edu.vn

Copyright © 2017 INSPIRE LIBRARY - TON DUC THANG UNIVERSITY

Searching Remote Databases, Please Wait