Language:

Cardiopulmonary Resuscitation-associated Lung Edema (CRALE). A Translational Study

American journal of respiratory and critical care medicine, 2021-02, Vol.203 (4), p.447-457 [Peer Reviewed Journal]

Copyright American Thoracic Society Feb 15, 2021 ;ISSN: 1073-449X ;EISSN: 1535-4970 ;DOI: 10.1164/rccm.201912-2454OC ;PMID: 32897758

Full text available

Citations Cited by

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
Cardiopulmonary Resuscitation-associated Lung Edema (CRALE). A Translational Study
Author: Magliocca, Aurora ; Rezoagli, Emanuele ; Zani, Davide ; Manfredi, Martina ; De Giorgio, Daria ; Olivari, Davide ; Fumagalli, Francesca ; Langer, Thomas ; Avalli, Leonello ; Grasselli, Giacomo ; Latini, Roberto ; Pesenti, Antonio ; Bellani, Giacomo ; Ristagno, Giuseppe
Subjects: Aged ; Cardiac function ; Cardiopulmonary resuscitation ; Cardiopulmonary Resuscitation - adverse effects ; Cardiopulmonary Resuscitation - methods ; CPR ; Edema ; Female ; Humans ; Lung diseases ; Lung Injury - etiology ; Male ; Mechanical properties ; Middle Aged ; Out-of-Hospital Cardiac Arrest - therapy ; Pressure - adverse effects ; Pulmonary Edema - etiology ; Translational Medical Research
Is Part Of: American journal of respiratory and critical care medicine, 2021-02, Vol.203 (4), p.447-457
Description: Cardiopulmonary resuscitation is the cornerstone of cardiac arrest (CA) treatment. However, lung injuries associated with it have been reported. To assess ) the presence and characteristics of lung abnormalities induced by cardiopulmonary resuscitation and ) the role of mechanical and manual chest compression (CC) in its development. This translational study included ) a porcine model of CA and cardiopulmonary resuscitation ( = 12) and ) a multicenter cohort of patients with out-of-hospital CA undergoing mechanical or manual CC ( = 52). Lung computed tomography performed after resuscitation was assessed qualitatively and quantitatively along with respiratory mechanics and gas exchanges. The lung weight in the mechanical CC group was higher compared with the manual CC group in the experimental (431 ± 127 vs. 273 ± 66, = 0.022) and clinical study (1,208 ± 630 vs. 837 ± 306, = 0.006). The mechanical CC group showed significantly lower oxygenation ( = 0.043) and respiratory system compliance ( < 0.001) compared with the manual CC group in the experimental study. The variation of right atrial pressure was significantly higher in the mechanical compared with the manual CC group (54 ± 11 vs. 31 ± 6 mm Hg, = 0.001) and significantly correlated with lung weight ( = 0.686, = 0.026) and respiratory system compliance ( = -0.634, = 0.027). Incidence of abnormal lung density was higher in patients treated with mechanical compared with manual CC (37% vs. 8%, = 0.018). This study demonstrated the presence of cardiopulmonary resuscitation-associated lung edema in animals and in patients with out-of-hospital CA, which is more pronounced after mechanical as opposed to manual CC and correlates with higher swings of right atrial pressure during CC.
Publisher: United States: American Thoracic Society
Language: English
Identifier: ISSN: 1073-449X
EISSN: 1535-4970
DOI: 10.1164/rccm.201912-2454OC
PMID: 32897758
Source: GFMER Free Medical Journals
MEDLINE
Alma/SFX Local Collection

Back to results list


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

Cardiopulmonary Resuscitation-associated Lung Edema (CRALE). A Translational Study

Copyright American Thoracic Society Feb 15, 2021 ;ISSN: 1073-449X ;EISSN: 1535-4970 ;DOI: 10.1164/rccm.201912-2454OC ;PMID: 32897758

Searching Remote Databases, Please Wait