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A Dedicated Population for Reward Coding in the Hippocampus

Neuron (Cambridge, Mass.), 2018-07, Vol.99 (1), p.179-193.e7 [Peer Reviewed Journal]

2018 Elsevier Inc. ;Copyright © 2018 Elsevier Inc. All rights reserved. ;2018. Elsevier Inc. ;ISSN: 0896-6273 ;EISSN: 1097-4199 ;DOI: 10.1016/j.neuron.2018.06.008 ;PMID: 30008297

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Title:
A Dedicated Population for Reward Coding in the Hippocampus
Author: Gauthier, Jeffrey L. ; Tank, David W.
Subjects: Animals ; Bias ; CA1 ; CA1 Region, Hippocampal - cytology ; CA1 Region, Hippocampal - diagnostic imaging ; CA1 Region, Hippocampal - physiology ; Computer applications ; Experiments ; Hippocampus ; Hippocampus - cytology ; Hippocampus - diagnostic imaging ; Hippocampus - physiology ; Mice ; Motivation ; navigation ; Neurons ; Neurons - cytology ; Neurons - physiology ; Optical Imaging ; place cells ; place fields ; Population ; Reinforcement ; Reward ; Spatial Navigation - physiology ; Stereotyped behavior ; Subiculum ; Task Performance and Analysis ; Transgenic animals ; Virtual Reality
Is Part Of: Neuron (Cambridge, Mass.), 2018-07, Vol.99 (1), p.179-193.e7
Description: The hippocampus plays a critical role in goal-directed navigation. Across different environments, however, hippocampal maps are randomized, making it unclear how goal locations could be encoded consistently. To address this question, we developed a virtual reality task with shifting reward contingencies to distinguish place versus reward encoding. In mice performing the task, large-scale recordings in CA1 and subiculum revealed a small, specialized cell population that was only active near reward yet whose activity could not be explained by sensory cues or stereotyped reward anticipation behavior. Across different virtual environments, most cells remapped randomly, but reward encoding consistently arose from a single pool of cells, suggesting that they formed a dedicated channel for reward. These observations represent a significant departure from the current understanding of CA1 as a relatively homogeneous ensemble without fixed coding properties and provide a new candidate for the cellular basis of goal memory in the hippocampus. [Display omitted] •The hippocampus contains a dedicated population of “reward cells”•Reward cells were active at multiple reward sites in one environment•Across environments, reward cell identity was preserved despite global remapping•Reward encoding could not be explained by reward anticipation behaviors Gauthier and Tank use in vivo imaging to identify a small population of CA1 and subiculum neurons specialized for encoding reward location. The same cells are active near multiple reward sites in one environment and even across environments during global remapping.
Publisher: United States: Elsevier Inc
Language: English
Identifier: ISSN: 0896-6273
EISSN: 1097-4199
DOI: 10.1016/j.neuron.2018.06.008
PMID: 30008297
Source: Cell Press Free Archives
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A Dedicated Population for Reward Coding in the Hippocampus

2018 Elsevier Inc. ;Copyright © 2018 Elsevier Inc. All rights reserved. ;2018. Elsevier Inc. ;ISSN: 0896-6273 ;EISSN: 1097-4199 ;DOI: 10.1016/j.neuron.2018.06.008 ;PMID: 30008297

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