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Apolipoprotein E gene variants shape the association between dietary fibre intake and cognitive decline risk in community-dwelling older adults

Age and ageing, 2023-01, Vol.52 (1) [Peer Reviewed Journal]

The Author(s) 2023. Published by Oxford University Press on behalf of the British Geriatrics Society. All rights reserved. For permissions, please email: journals.permissions@oup.com. 2023 ;The Author(s) 2023. Published by Oxford University Press on behalf of the British Geriatrics Society. All rights reserved. For permissions, please email: journals.permissions@oup.com. ;ISSN: 0002-0729 ;EISSN: 1468-2834 ;DOI: 10.1093/ageing/afac329 ;PMID: 36729469

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  • Title:
    Apolipoprotein E gene variants shape the association between dietary fibre intake and cognitive decline risk in community-dwelling older adults
  • Author: Unión-Caballero, Andrea ; Meroño, Tomás ; Andrés-Lacueva, Cristina ; Hidalgo-Liberona, Nicole ; Rabassa, Montserrat ; Bandinelli, Stefania ; Ferrucci, Luigi ; Fedecostante, Massimiliano ; Zamora-Ros, Raúl ; Cherubini, Antonio
  • Subjects: Aged ; Aging ; Apolipoprotein E4 - genetics ; Apolipoproteins E - genetics ; Cognitive Dysfunction - diagnosis ; Cognitive Dysfunction - epidemiology ; Cognitive Dysfunction - genetics ; Cohort Studies ; Female ; Humans ; Independent Living ; Male ; Research Paper
  • Is Part Of: Age and ageing, 2023-01, Vol.52 (1)
  • Description: Abstract Background healthy dietary patterns have been associated with lower risk for age-related cognitive decline. However, little is known about the specific role of dietary fibre on cognitive decline in older adults. Objective this study aimed to examine the association between dietary fibre and cognitive decline in older adults and to assess the influence of genetic, lifestyle and clinical characteristics in this association. Design and participants the Invecchiare in Chianti, aging in the Chianti area study is a cohort study of community-dwelling older adults from Italy. Cognitive function, dietary and clinical data were collected at baseline and years 3, 6, 9 and 15. Our study comprised 848 participants aged ≥ 65 years (56% female) with 2,038 observations. Main outcome and measures cognitive decline was defined as a decrease ≥3 units in the Mini-Mental State Examination score during consecutive visits. Hazard ratios for cognitive decline were estimated using time-dependent Cox regression models. Results energy-adjusted fibre intake was not associated with cognitive decline during the 15-years follow-up (P > 0.05). However, fibre intake showed a significant interaction with Apolipoprotein E (APOE) haplotype for cognitive decline (P = 0.02). In participants with APOE-ɛ4 haplotype, an increase in 5 g/d of fibre intake was significantly associated with a 30% lower risk for cognitive decline. No association was observed in participants with APOE-ɛ2 and APOE-ɛ3 haplotypes. Conclusions and relevance dietary fibre intake was not associated with cognitive decline amongst older adults for 15 years of follow-up. Nonetheless, older subjects with APOE-ɛ4 haplotype may benefit from higher fibre intakes based on the reduced risk for cognitive decline in this high-risk group.
  • Publisher: England: Oxford University Press
  • Language: English
  • Identifier: ISSN: 0002-0729
    EISSN: 1468-2834
    DOI: 10.1093/ageing/afac329
    PMID: 36729469
  • Source: GFMER Free Medical Journals
    MEDLINE
    Alma/SFX Local Collection
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