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Whole-genome sequencing of 175 Mongolians uncovers population-specific genetic architecture and gene flow throughout North and East Asia

Nature genetics, 2018-12, Vol.50 (12), p.1696-1704 [Peer Reviewed Journal]

COPYRIGHT 2018 Nature Publishing Group ;Copyright Nature Publishing Group Dec 2018 ;ISSN: 1061-4036 ;EISSN: 1546-1718 ;DOI: 10.1038/s41588-018-0250-5 ;PMID: 30397334

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Title:
Whole-genome sequencing of 175 Mongolians uncovers population-specific genetic architecture and gene flow throughout North and East Asia
Author: Bai, Haihua ; Guo, Xiaosen ; Narisu, Narisu ; Lan, Tianming ; Wu, Qizhu ; Xing, Yanping ; Zhang, Yong ; Bond, Stephen R ; Pei, Zhili ; Zhang, Yanru ; Zhang, Dandan ; Jirimutu, Jirimutu ; Zhang, Dong ; Yang, Xukui ; Morigenbatu, Morigenbatu ; Zhang, Li ; Ding, Bingyi ; Guan, Baozhu ; Cao, Junwei ; Lu, Haorong ; Liu, Yiyi ; Li, Wangsheng ; Dang, Ningxin ; Jiang, Mingyang ; Wang, Shenyuan ; Xu, Huixin ; Wang, Dingzhu ; Liu, Chunxia ; Luo, Xin ; Gao, Ying ; Li, Xueqiong ; Wu, Zongze ; Yang, Liqing ; Meng, Fanhua ; Ning, Xiaolian ; Hashenqimuge, Hashenqimuge ; Wu, Kaifeng ; Wang, Bo ; Suyalatu, Suyalatu ; Liu, Yingchun ; Ye, Chen ; Wu, Huiguang ; Leppälä, Kalle ; Li, Lu ; Fang, Lin ; Chen, Yujie ; Xu, Wenhao ; Li, Tao ; Liu, Xin ; Xu, Xun ; Gignoux, Christopher R ; Yang, Huanming ; Brody, Lawrence C ; Wang, Jun ; Kristiansen, Karsten ; Burenbatu, Burenbatu ; Zhou, Huanmin ; Yin, Ye
Subjects: Americas - epidemiology ; Analysis ; Asia, Northern - epidemiology ; Asians - ethnology ; Asians - genetics ; Asians - statistics & numerical data ; Bioinformatics ; Demographics ; Deoxyribonucleic acid ; DNA ; DNA sequencing ; Europe - epidemiology ; Far East - epidemiology ; Female ; Gene Flow ; Gene sequencing ; Genetic aspects ; Genetic diversity ; Genetics ; Genetics, Population ; Genome, Human ; Genomes ; Haplotypes ; Health aspects ; Humans ; Male ; Methods ; Minority & ethnic groups ; Mitochondrial DNA ; Mongolia - ethnology ; Mongols ; Multiculturalism & pluralism ; Nucleotide sequencing ; Phylogenetics ; Phylogeny ; Population ; Population genetics ; Populations ; Variation ; Whole Genome Sequencing
Is Part Of: Nature genetics, 2018-12, Vol.50 (12), p.1696-1704
Description: The genetic variation in Northern Asian populations is currently undersampled. To address this, we generated a new genetic variation reference panel by whole-genome sequencing of 175 ethnic Mongolians, representing six tribes. The cataloged variation in the panel shows strong population stratification among these tribes, which correlates with the diverse demographic histories in the region. Incorporating our results with the 1000 Genomes Project panel identifies derived alleles shared between Finns and Mongolians/Siberians, suggesting that substantial gene flow between northern Eurasian populations has occurred in the past. Furthermore, we highlight that North, East, and Southeast Asian populations are more aligned with each other than these groups are with South Asian and Oceanian populations.
Publisher: United States: Nature Publishing Group
Language: English
Identifier: ISSN: 1061-4036
EISSN: 1546-1718
DOI: 10.1038/s41588-018-0250-5
PMID: 30397334
Source: GFMER Free Medical Journals
MEDLINE
ProQuest Central

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Whole-genome sequencing of 175 Mongolians uncovers population-specific genetic architecture and gene flow throughout North and East Asia

COPYRIGHT 2018 Nature Publishing Group ;Copyright Nature Publishing Group Dec 2018 ;ISSN: 1061-4036 ;EISSN: 1546-1718 ;DOI: 10.1038/s41588-018-0250-5 ;PMID: 30397334

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