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Invited Commentary: From Genome-Wide Association Studies to Gene-Environment-Wide Interaction Studies—Challenges and Opportunities

American journal of epidemiology, 2009-01, Vol.169 (2), p.227-230 [Peer Reviewed Journal]

American Journal of Epidemiology © The Author 2008. Published by the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org. 2009 ;American Journal of Epidemiology © The Author 2008. Published by the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org. ;ISSN: 0002-9262 ;EISSN: 1476-6256 ;DOI: 10.1093/aje/kwn351 ;PMID: 19022826

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Title:
Invited Commentary: From Genome-Wide Association Studies to Gene-Environment-Wide Interaction Studies—Challenges and Opportunities
Author: Khoury, Muin J. ; Wacholder, Sholom
Subjects: Environment ; Epidemiologic Methods ; Epidemiology ; Gene Expression Regulation ; Genetic Markers ; Genetic Predisposition to Disease ; Genetic research ; genetics ; Genome, Human ; Genome-Wide Association Study ; Genomics ; Humans ; Models, Genetic ; Polymorphism, Single Nucleotide ; Practice of Epidemiology ; Risk Assessment ; Risk Factors
Is Part Of: American journal of epidemiology, 2009-01, Vol.169 (2), p.227-230
Description: The recent success of genome-wide association studies in finding susceptibility genes for many common diseases presents tremendous opportunities for epidemiologic studies of environmental risk factors. Analysis of gene-environment interactions, included in only a small fraction of epidemiologic studies until now, will begin to accelerate as investigators integrate analyses of genome-wide variation and environmental factors. Nevertheless, considerable methodological challenges are involved in the design and analysis of gene-environment interaction studies. The authors review these issues in the context of evolving methods for assessing interactions and discuss how the current agnostic approach to interrogating the human genome for genetic risk factors could be extended into a similar approach to gene-environment-wide interaction studies of disease occurrence in human populations.
Publisher: United States: Oxford University Press
Language: English
Identifier: ISSN: 0002-9262
EISSN: 1476-6256
DOI: 10.1093/aje/kwn351
PMID: 19022826
Source: Geneva Foundation Free Medical Journals at publisher websites
MEDLINE
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Invited Commentary: From Genome-Wide Association Studies to Gene-Environment-Wide Interaction Studies—Challenges and Opportunities

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