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The carbohydrate-active enzyme database: functions and literature

Nucleic acids research, 2022-01, Vol.50 (D1), p.D571-D577 [Peer Reviewed Journal]

The Author(s) 2021. Published by Oxford University Press on behalf of Nucleic Acids Research. 2022 ;The Author(s) 2021. Published by Oxford University Press on behalf of Nucleic Acids Research. ;Distributed under a Creative Commons Attribution 4.0 International License ;ISSN: 0305-1048 ;EISSN: 1362-4962 ;DOI: 10.1093/nar/gkab1045 ;PMID: 34850161

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  • Title:
    The carbohydrate-active enzyme database: functions and literature
  • Author: Drula, Elodie ; Garron, Marie-Line ; Dogan, Suzan ; Lombard, Vincent ; Henrissat, Bernard ; Terrapon, Nicolas
  • Subjects: Carbohydrates ; Carbohydrates - chemistry ; Carbohydrates - classification ; Database Issue ; Databases, Nucleic Acid ; Databases, Protein ; Enzyme Activation ; Enzyme Activation - genetics ; Enzymes ; Enzymes - chemistry ; Enzymes - classification ; Humans ; Life Sciences
  • Is Part Of: Nucleic acids research, 2022-01, Vol.50 (D1), p.D571-D577
  • Description: Abstract Thirty years have elapsed since the emergence of the classification of carbohydrate-active enzymes in sequence-based families that became the CAZy database over 20 years ago, freely available for browsing and download atĀ www.cazy.org. In the era of large scale sequencing and high-throughput Biology, it is important to examine the position of this specialist database that is deeply rooted in human curation. The three primary tasks of the CAZy curators are (i) to maintain and update the family classification of this class of enzymes, (ii) to classify sequences newly released by GenBank and the Protein Data Bank and (iii) to capture and present functional information for each family. The CAZy website is updated once a month. Here we briefly summarize the increase in novel families and the annotations conducted during the last 8 years. We present several important changes that facilitate taxonomic navigation, and allow to download the entirety of the annotations. Most importantly we highlight the considerable amount of work that accompanies the analysis and report of biochemical data from the literature.
  • Publisher: England: Oxford University Press
  • Language: English
  • Identifier: ISSN: 0305-1048
    EISSN: 1362-4962
    DOI: 10.1093/nar/gkab1045
    PMID: 34850161
  • Source: Oxford Journals Open Access Collection
    Geneva Foundation Free Medical Journals at publisher websites
    Hyper Article en Ligne (HAL) (Open Access)
    MEDLINE
    PubMed Central
    DOAJ Directory of Open Access Journals

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