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Risk Factors for Calcific Aortic Valve Disease in Afghan Population

Vascular health and risk management, 2022-08, Vol.18, p.643-652 [Peer Reviewed Journal]

COPYRIGHT 2022 Dove Medical Press Limited ;2022. This work is licensed under https://creativecommons.org/licenses/by-nc/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;2022 Sherzad et al. 2022 Sherzad et al. ;ISSN: 1178-2048 ;ISSN: 1176-6344 ;EISSN: 1178-2048 ;DOI: 10.2147/VHRM.S376955 ;PMID: 36003849

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Title:
Risk Factors for Calcific Aortic Valve Disease in Afghan Population
Author: Sherzad, Abdul Ghafar ; Shinwari, Muhibullah ; Azimee, M. Azim ; Nemat, Arash ; Zeng, Qingchun
Subjects: Age ; Angina pectoris ; Aortic stenosis ; aortic valve calcification ; aortic valve sclerosis ; Aortic valve stenosis ; Atherosclerosis ; Blood pressure ; Body mass index ; Calcification ; Cardiovascular disease ; Cholesterol ; Coronary vessels ; Diabetes ; Disease prevention ; Family medical history ; Heart attacks ; High density lipoprotein ; Hypertension ; independent risk factors ; Lipoproteins ; Medical records ; Medical research ; Medicine, Experimental ; Mortality ; Obesity ; Original Research ; Population ; Risk factors ; risk factors for atherosclerosis
Is Part Of: Vascular health and risk management, 2022-08, Vol.18, p.643-652
Description: Objective: Evidence from previous studies suggests that calcific aortic valve disease (CAVD) is not an unavoidable consequence of aging, and may be linked to explicit risk factors. However, little is known regarding the Afghan population in this context. The current study aimed to identify the clinical features of CAVD and determine independent risk factors for CAVD in the Afghan population. Patients and Methods: A case-control study was conducted among 1072 Afghan participants (age >18 years) from January 2018 to December 2020. The study participants were divided into two groups based on echocardiographic findings: 536 individuals with CAVD and 536 age- and sex-matched controls. Data were collected using questionnaires from the medical records of all cases and controls. The independent predictors of CAVD were evaluated using multivariate logistic regression analysis. Results: The mean age of study participants was 65.3 [+ or -] 13.5 years (range, 20-100 years). Of the 536 patients with CAVD, 77 (14.4%) had aortic valve stenosis, 415 (77.4%) had aortic valve calcification, and 44 (8.2%) had bicuspid aortic valve. Multivariate logistic regression analysis revealed that sedentary lifestyle (odds ratio [OR] = 2.517, p = 003), diabetes mellitus (DM) (OR = 1.902, p = 006), high body mass index (BMI > 30 kg/[m.sup.2]) (OR = 1.776, p = 005), good socioeconomic status (OR = 1.724, p = 021), and hypertension (OR = 1.664, p <0.001) were independent risk factors for CAVD in the Afghan population. Conclusion: It was observed that sedentary lifestyle, diabetes mellitus, high BMI (> 30 kg/[m.sup.2]), good socioeconomic status, and hypertension are independent risk factors for the development of CAVD compared to those with a normal aortic valve in the Afghan population. Keywords: aortic valve sclerosis, aortic valve calcification, aortic valve stenosis, risk factors for atherosclerosis, independent risk factors
Publisher: Macclesfield: Dove Medical Press Limited
Language: English
Identifier: ISSN: 1178-2048
ISSN: 1176-6344
EISSN: 1178-2048
DOI: 10.2147/VHRM.S376955
PMID: 36003849
Source: Geneva Foundation Free Medical Journals at publisher websites
PubMed Central
ProQuest Central
DOAJ Directory of Open Access Journals
Dove Press Free

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Risk Factors for Calcific Aortic Valve Disease in Afghan Population

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