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Correlation between plasma levels of arginine and citrulline in preterm and full‐term neonates: Therapeutical implications

Journal of clinical laboratory analysis, 2017-11, Vol.31 (6), p.n/a [Peer Reviewed Journal]

2017 Wiley Periodicals, Inc. ;Copyright © 2017 Wiley Periodicals, Inc. ;ISSN: 0887-8013 ;EISSN: 1098-2825 ;DOI: 10.1002/jcla.22134 ;PMID: 28169465

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Title:
Correlation between plasma levels of arginine and citrulline in preterm and full‐term neonates: Therapeutical implications
Author: Contreras, Mike T. ; Gallardo, Maria J. ; Betancourt, Luis R. ; Rada, Pedro V. ; Ceballos, Gerardo A. ; Hernandez, Luis E. ; Hernandez, Luis F.
Subjects: amino acids ; Arginine ; Arginine - blood ; capillary ; Capillary electrophoresis ; Citrulline ; Citrulline - blood ; Cohort Studies ; electrophoresis ; Electrophoresis, Capillary ; Female ; fluorescence ; Humans ; infant ; Infant, Newborn ; Infant, Newborn, Diseases - blood ; Infant, Newborn, Diseases - epidemiology ; Infant, Premature - blood ; Infant, Premature, Diseases - blood ; Infant, Premature, Diseases - epidemiology ; Male ; Neonates ; Nitric Oxide ; Plasma levels ; premature ; Premature birth ; Respiratory therapy ; Spectrometry, Fluorescence ; Statistical analysis
Is Part Of: Journal of clinical laboratory analysis, 2017-11, Vol.31 (6), p.n/a
Description: Background Preterm neonates exhibit several deficiencies that endanger their lives. Understanding those disturbances will provide tools for the management of preterm neonates. The present work focuses on arginine and citrulline which has been flagged among the biochemical landmarks of prematurity. Methods We examined blood samples of preterm newborns as compared with mature neonates to determine the levels of arginine and citrulline by capillary zone electrophoresis with laser induced fluorescence detection (CZE‐LIFD). Results Significantly lower levels of arginine and citrulline were found in preterm neonates than in mature neonates (P<.01). Interestingly there was a highly significant correlation between the two amino acids in mature neonates (P<.0001). Such correlation was present in preterm neonates too (P<.01). Pearson coefficient showed that 60% of the citrulline concentration depends on arginine concentration in mature neonates. Only 20% of the citrulline concentration depends on arginine concentration in preterm neonates. Although the ratio arginine/citrulline was lower in preterm neonates than in mature neonates the difference was not statistically significant. Conclusions These results suggest that less arginine is converted to citrulline to form nitric oxide in preterm than in full‐term neonates. The result is discussed in terms of the immature enzymatic systems in the preterm neonate.
Publisher: United States: John Wiley & Sons, Inc
Language: English
Identifier: ISSN: 0887-8013
EISSN: 1098-2825
DOI: 10.1002/jcla.22134
PMID: 28169465
Source: Journals@Ovid Open Access Journal Collection Rolling
MEDLINE
PubMed Central

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Correlation between plasma levels of arginine and citrulline in preterm and full‐term neonates: Therapeutical implications

2017 Wiley Periodicals, Inc. ;Copyright © 2017 Wiley Periodicals, Inc. ;ISSN: 0887-8013 ;EISSN: 1098-2825 ;DOI: 10.1002/jcla.22134 ;PMID: 28169465

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