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Prenatal Polycyclic Aromatic Hydrocarbon (PAH) Exposure and Child Behavior at Age 6-7 Years

Environmental health perspectives, 2012-06, Vol.120 (6), p.921-926 [Tạp chí có phản biện]

2015 INIST-CNRS ;COPYRIGHT 2012 National Institute of Environmental Health Sciences ;COPYRIGHT 2012 National Institute of Environmental Health Sciences ;Copyright National Institute of Environmental Health Sciences Jun 2012 ;2012 ;ISSN: 0091-6765 ;EISSN: 1552-9924 ;DOI: 10.1289/ehp.1104315 ;PMID: 22440811 ;CODEN: EVHPAZ

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Nhan đề:
Prenatal Polycyclic Aromatic Hydrocarbon (PAH) Exposure and Child Behavior at Age 6-7 Years
Tác giả: Perera, Frederica P. ; Tang, Deliang ; Wang, Shuang ; Vishnevetsky, Julia ; Zhang, Bingzhi ; Diaz, Diurka ; Camann, David ; Rauh, Virginia
Chủ đề: Adducts ; African Americans ; Air ; Air Pollutants - blood ; Air Pollutants - toxicity ; Anxiety ; Anxiety Disorders - chemically induced ; Anxiety Disorders - epidemiology ; Anxiety Disorders - ethnology ; Attention Deficit Disorder with Hyperactivity - chemically induced ; Attention Deficit Disorder with Hyperactivity - epidemiology ; Attention Deficit Disorder with Hyperactivity - ethnology ; Attention-deficit hyperactivity disorder ; Behavior ; Biological and medical sciences ; Biomarkers - blood ; Carcinogenesis, carcinogens and anticarcinogens ; Chemical agents ; Chemical hazards ; Child ; Child Behavior - drug effects ; Children ; Children's Health ; Chromatography, High Pressure Liquid ; Cord blood ; Development and progression ; Dominican Republic - ethnology ; Environment. Living conditions ; Environmental health ; Environmental pollutants toxicology ; Female ; Fluorescence ; Health aspects ; Health outcomes ; Humans ; Logistic Models ; Medical sciences ; Multivariate Analysis ; New York City - epidemiology ; Polycyclic aromatic hydrocarbons ; Polycyclic Aromatic Hydrocarbons - blood ; Polycyclic Aromatic Hydrocarbons - toxicity ; Pregnancy ; Pregnant women ; Prenatal Exposure Delayed Effects - epidemiology ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Risk factors ; Secondhand smoke ; Toxicology ; Tumors
Là 1 phần của: Environmental health perspectives, 2012-06, Vol.120 (6), p.921-926
Mô tả: Background: Airborne polycyclic aromatic hydrocarbons (PAH) are widespread urban air pollutants from fossil fuel burning and other combustion sources. We previously reported that a broad spectrum of combustion-related DNA adducts in cord blood was associated with attention problems at 6—7 years of age in the Columbia Center for Children's Environmental Health (CCCEH) longitudinal cohort study. Objectives: We evaluated the relationship between behavioral problems and two different measures of prenatal exposure—both specific to PAH—in the same cohort. Methods: Children of nonsmoking African-American and Dominican women in New York City (NYC) were followed from in utero to 6-7 years. Prenatal PAH exposure was estimated by personal air monitoring of the mothers during pregnancy as well as by the measurement of DNA adducts specific to benzo[a]pyrene (BaP), a representative PAH, in maternal and cord blood. At 6-7 years of age, child behavior was assessed using the Child Behavior Checklist (CBCL) (n = 253). Generalized linear models were used to test the association between prenatal PAH exposure and behavioral outcomes. Results: In multivariate analyses, high prenatal PAH exposure, whether characterized by personal air monitoring (greater than the median of 2.27 ng/m³) or maternal and cord adducts (detectable or higher), was positively associated with symptoms of Anxious/Depressed and Attention Problems (p ≤ 0.05). Conclusion: These results provide additional evidence that environmental levels of PAH encountered in NYC air can adversely affect child behavior.
Nơi xuất bản: Research Triangle Park, NC: National Institute of Environmental Health Sciences
Ngôn ngữ: English
Số nhận dạng: ISSN: 0091-6765
EISSN: 1552-9924
DOI: 10.1289/ehp.1104315
PMID: 22440811
CODEN: EVHPAZ
Nguồn: US Government Documents
MEDLINE
PubMed Central
ProQuest Central
DOAJ Directory of Open Access Journals

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Prenatal Polycyclic Aromatic Hydrocarbon (PAH) Exposure and Child Behavior at Age 6-7 Years

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