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Feasibility Study on Cardiac Arrhythmia Ablation Using High-Energy Heavy Ion Beams

Scientific reports, 2016-12, Vol.6 (1), p.38895-38895, Article 38895 [Peer Reviewed Journal]

Copyright Nature Publishing Group Dec 2016 ;Copyright © 2016, The Author(s) 2016 The Author(s) ;ISSN: 2045-2322 ;EISSN: 2045-2322 ;DOI: 10.1038/srep38895 ;PMID: 27996023

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Title:
Feasibility Study on Cardiac Arrhythmia Ablation Using High-Energy Heavy Ion Beams
Author: Lehmann, H Immo ; Graeff, Christian ; Simoniello, Palma ; Constantinescu, Anna ; Takami, Mitsuru ; Lugenbiel, Patrick ; Richter, Daniel ; Eichhorn, Anna ; Prall, Matthias ; Kaderka, Robert ; Fiedler, Fine ; Helmbrecht, Stephan ; Fournier, Claudia ; Erbeldinger, Nadine ; Rahm, Ann-Kathrin ; Rivinius, Rasmus ; Thomas, Dierk ; Katus, Hugo A ; Johnson, Susan B ; Parker, Kay D ; Debus, Jürgen ; Asirvatham, Samuel J ; Bert, Christoph ; Durante, Marco ; Packer, Douglas L
Subjects: Ablation ; Animals ; Apoptosis ; Apoptosis - radiation effects ; Arrhythmia ; Arrhythmias, Cardiac - diagnostic imaging ; Arrhythmias, Cardiac - metabolism ; Arrhythmias, Cardiac - pathology ; Arrhythmias, Cardiac - radiotherapy ; Cancer ; Cardiac arrhythmia ; Conduction ; Dose-Response Relationship, Radiation ; Energy ; Feasibility studies ; Female ; Fibrosis ; Heart ; Heart diseases ; Ion beams ; Ionizing radiation ; Male ; Mapping ; Myocardium - metabolism ; Myocardium - pathology ; Positron emission tomography ; Radiotherapy, High-Energy - methods ; Sus scrofa ; Ultrasound ; Ventricle
Is Part Of: Scientific reports, 2016-12, Vol.6 (1), p.38895-38895, Article 38895
Description: High-energy ion beams are successfully used in cancer therapy and precisely deliver high doses of ionizing radiation to small deep-seated target volumes. A similar noninvasive treatment modality for cardiac arrhythmias was tested here. This study used high-energy carbon ions for ablation of cardiac tissue in pigs. Doses of 25, 40, and 55 Gy were applied in forced-breath-hold to the atrioventricular junction, left atrial pulmonary vein junction, and freewall left ventricle of intact animals. Procedural success was tracked by (1.) in-beam positron-emission tomography (PET) imaging; (2.) intracardiac voltage mapping with visible lesion on ultrasound; (3.) lesion outcomes in pathohistolgy. High doses (40-55 Gy) caused slowing and interruption of cardiac impulse propagation. Target fibrosis was the main mediator of the ablation effect. In irradiated tissue, apoptosis was present after 3, but not 6 months. Our study shows feasibility to use high-energy ion beams for creation of cardiac lesions that chronically interrupt cardiac conduction.
Publisher: England: Nature Publishing Group
Language: English
Identifier: ISSN: 2045-2322
EISSN: 2045-2322
DOI: 10.1038/srep38895
PMID: 27996023
Source: MEDLINE
PubMed Central
ProQuest Central
DOAJ Directory of Open Access Journals

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Feasibility Study on Cardiac Arrhythmia Ablation Using High-Energy Heavy Ion Beams

Copyright Nature Publishing Group Dec 2016 ;Copyright © 2016, The Author(s) 2016 The Author(s) ;ISSN: 2045-2322 ;EISSN: 2045-2322 ;DOI: 10.1038/srep38895 ;PMID: 27996023

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