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Blood miRNAs as Potential Diagnostic Biomarkers for Chronic Obstructive Pulmonary Disease: A Meta-Analysis

International journal of chronic obstructive pulmonary disease, 2024-01, Vol.19, p.981-993 [Peer Reviewed Journal]

2024 Li et al. ;2024 Li et al. 2024 Li et al. ;ISSN: 1176-9106 ;EISSN: 1178-2005 ;DOI: 10.2147/COPD.S457172 ;PMID: 38715982

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Title:
Blood miRNAs as Potential Diagnostic Biomarkers for Chronic Obstructive Pulmonary Disease: A Meta-Analysis
Author: Li, Xiaohua ; Fu, Guoxia ; Zhang, Chunrong ; Wu, Yu ; Guo, Hua ; Li, Weiming ; Zeng, Xuefeng
Subjects: Aged ; Area Under Curve ; biomarker ; Biomarkers - blood ; chronic obstructive pulmonary disease ; Circulating MicroRNA - blood ; Circulating MicroRNA - genetics ; diagnosis ; Female ; Genetic Markers ; Humans ; Lung - physiopathology ; Male ; meta-analysis ; MicroRNAs - blood ; Middle Aged ; mirnas ; Odds Ratio ; Predictive Value of Tests ; Prognosis ; Pulmonary Disease, Chronic Obstructive - blood ; Pulmonary Disease, Chronic Obstructive - diagnosis ; Pulmonary Disease, Chronic Obstructive - genetics ; Review ; ROC Curve
Is Part Of: International journal of chronic obstructive pulmonary disease, 2024-01, Vol.19, p.981-993
Description: Investigate the efficacy of blood microRNAs (miRNAs) as diagnostic biomarkers for Chronic Obstructive Pulmonary Disease (COPD). We conducted a comprehensive search in English and Chinese databases, selecting studies based on predetermined criteria. Diagnostic parameters like summarized sensitivity (SSEN), summarized specificity (SSPE), summarized positive likelihood ratio (SPLR), summarized negative likelihood ratio (SNLR), and diagnostic odds ratio (DOR), and area under the curve (AUC) of the summary receiver operating characteristic (SROC) curves were analyzed using a bivariate model. Each parameter was accompanied by a 95% confidence interval (CI). Eighteen high-quality studies were included. For diagnosing COPD with blood miRNAs, the SSEN was 0.83 (95% CI 0.76-0.89), SSPE 0.76 (95% CI 0.70-0.82), SPLR 3.50 (95% CI 2.66-4.60), SNLR 0.22 (95% CI 0.15-0.33), DOR 15.72 (95% CI 8.58-28.77), and AUC 0.86 (95% CI 0.82-0.88). In acute exacerbations, SSEN was 0.85 (95% CI 0.76-0.91), SSPE 0.80 (95% CI 0.73-0.86), SPLR 4.26 (95% CI 3.05-5.95), SNLR 0.19 (95% CI 0.12-0.30), DOR 22.29 (95% CI 11.47-43.33), and AUC 0.89 (95% CI 0.86-0.91). Blood miRNAs demonstrate significant accuracy in diagnosing COPD, both in general and during acute exacerbations, suggesting their potential as reliable biomarkers.
Publisher: New Zealand: Dove
Language: English
Identifier: ISSN: 1176-9106
EISSN: 1178-2005
DOI: 10.2147/COPD.S457172
PMID: 38715982
Source: GFMER Free Medical Journals
MEDLINE
PubMed Central
DOVE Medical Press Journals
ProQuest Central
DOAJ Directory of Open Access Journals

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Blood miRNAs as Potential Diagnostic Biomarkers for Chronic Obstructive Pulmonary Disease: A Meta-Analysis

2024 Li et al. ;2024 Li et al. 2024 Li et al. ;ISSN: 1176-9106 ;EISSN: 1178-2005 ;DOI: 10.2147/COPD.S457172 ;PMID: 38715982

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