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Obesity, Polycystic Ovary Syndrome, and Infertility: A New Avenue for GLP-1 Receptor Agonists

The journal of clinical endocrinology and metabolism, 2020-08, Vol.105 (8), p.e2695-e2709 [Peer Reviewed Journal]

Endocrine Society 2020. 2020 ;Endocrine Society 2020. ;COPYRIGHT 2020 Oxford University Press ;ISSN: 0021-972X ;EISSN: 1945-7197 ;DOI: 10.1210/clinem/dgaa285 ;PMID: 32442310

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Title:
Obesity, Polycystic Ovary Syndrome, and Infertility: A New Avenue for GLP-1 Receptor Agonists
Author: Cena, Hellas ; Chiovato, Luca ; Nappi, Rossella E
Subjects: Agonists ; Body mass index ; Body weight ; Body weight loss ; Diabetes mellitus ; Drug Therapy, Combination ; Fecundity ; Female ; Glucagon ; Glucagon-like peptide 1 ; Glucagon-Like Peptide-1 Receptor - agonists ; Glucagon-Like Peptide-1 Receptor - metabolism ; Humans ; Incretins - pharmacology ; Incretins - therapeutic use ; Infertility ; Infertility, Female - blood ; Infertility, Female - drug therapy ; Infertility, Female - etiology ; Infertility, Female - metabolism ; Insulin ; Insulin resistance ; Liraglutide ; Liraglutide - pharmacology ; Liraglutide - therapeutic use ; Menstruation ; Metformin ; Metformin - therapeutic use ; Obesity ; Obesity - blood ; Obesity - complications ; Obesity - drug therapy ; Obesity - metabolism ; Online Only ; Ovaries ; Overweight ; Patients ; Polycystic ovary syndrome ; Polycystic Ovary Syndrome - blood ; Polycystic Ovary Syndrome - complications ; Polycystic Ovary Syndrome - drug therapy ; Polycystic Ovary Syndrome - metabolism ; Pregnancy ; Prognosis ; Randomized Controlled Trials as Topic ; Stein-Leventhal syndrome ; Testosterone ; Testosterone - blood ; Testosterone - metabolism ; Treatment Outcome ; Type 2 diabetes ; Weight control ; Weight Loss - drug effects
Is Part Of: The journal of clinical endocrinology and metabolism, 2020-08, Vol.105 (8), p.e2695-e2709
Description: Abstract Context Obesity is responsible for an increased risk of sub-fecundity and infertility. Obese women show poorer reproductive outcomes regardless of the mode of conception, and higher body mass index (BMI) is associated with poorer fertility prognosis. Polycystic ovary syndrome (PCOS) is one of the leading causes of infertility, and many women with PCOS are also overweight or obese. Evidence Acquisition The aim of the present narrative review is to describe the mechanisms responsible for the development of infertility and PCOS in women with obesity/overweight, with a focus on the emerging role of glucagon-like peptide-1 (GLP-1) receptor agonists (GLP-1 RAs) as a therapeutic option for obese women with PCOS. Evidence synthesis Weight reduction represents the most significant factor affecting fertility and pregnancy outcomes. Current experimental and clinical evidence suggests the presence of an underlying pathophysiological link between obesity, GLP-1 kinetic alterations, and PCOS pathogenesis. Based on the positive results in patients affected by obesity, with or without diabetes, the administration of GLP-1 RA (mainly liraglutide) alone or in combination with metformin has been investigated in women with obesity and PCOS. Several studies demonstrated significant weight loss and testosterone reduction, with mixed results relative to improvements in insulin resistance parameters and menstrual patterns. Conclusions The weight loss effects of GLP-1 RA offer a unique opportunity to expand the treatment options available to PCOS patients.
Publisher: US: Oxford University Press
Language: English
Identifier: ISSN: 0021-972X
EISSN: 1945-7197
DOI: 10.1210/clinem/dgaa285
PMID: 32442310
Source: Oxford Journals Open Access Collection
GFMER Free Medical Journals
MEDLINE
Alma/SFX Local Collection

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Obesity, Polycystic Ovary Syndrome, and Infertility: A New Avenue for GLP-1 Receptor Agonists

Endocrine Society 2020. 2020 ;Endocrine Society 2020. ;COPYRIGHT 2020 Oxford University Press ;ISSN: 0021-972X ;EISSN: 1945-7197 ;DOI: 10.1210/clinem/dgaa285 ;PMID: 32442310

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