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Auditory dysfunction in schizophrenia: integrating clinical and basic features

Nature reviews. Neuroscience, 2015-09, Vol.16 (9), p.535-550 [Peer Reviewed Journal]

COPYRIGHT 2015 Nature Publishing Group ;Copyright Nature Publishing Group Sep 2015 ;ISSN: 1471-003X ;EISSN: 1471-0048 ;DOI: 10.1038/nrn4002 ;PMID: 26289573

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Title:
Auditory dysfunction in schizophrenia: integrating clinical and basic features
Author: Javitt, Daniel C ; Sweet, Robert A
Subjects: Acoustic Stimulation - methods ; Amphetamines ; Antipsychotics ; Auditory Cortex - pathology ; Auditory Cortex - physiopathology ; Auditory Pathways - pathology ; Auditory Pathways - physiopathology ; Bats ; Development and progression ; Dopamine ; Electroencephalography - methods ; Hearing disorders ; Humans ; Mental disorders ; Neurosciences ; Physiological aspects ; Psychotropic drugs ; Schizophrenia ; Schizophrenia - diagnosis ; Schizophrenia - physiopathology ; Schizophrenic Psychology
Is Part Of: Nature reviews. Neuroscience, 2015-09, Vol.16 (9), p.535-550
Description: Schizophrenia is a complex neuropsychiatric disorder that is associated with persistent psychosocial disability in affected individuals. Although studies of schizophrenia have traditionally focused on deficits in higher-order processes such as working memory and executive function, there is an increasing realization that, in this disorder, deficits can be found throughout the cortex and are manifest even at the level of early sensory processing. These deficits are highly amenable to translational investigation and represent potential novel targets for clinical intervention. Deficits, moreover, have been linked to specific structural abnormalities in post-mortem auditory cortex tissue from individuals with schizophrenia, providing unique insights into underlying pathophysiological mechanisms.
Publisher: England: Nature Publishing Group
Language: English
Identifier: ISSN: 1471-003X
EISSN: 1471-0048
DOI: 10.1038/nrn4002
PMID: 26289573
Source: ProQuest One Psychology
MEDLINE
ProQuest Central

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Auditory dysfunction in schizophrenia: integrating clinical and basic features

COPYRIGHT 2015 Nature Publishing Group ;Copyright Nature Publishing Group Sep 2015 ;ISSN: 1471-003X ;EISSN: 1471-0048 ;DOI: 10.1038/nrn4002 ;PMID: 26289573

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