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Coronary microvascular dysfunction in stable ischaemic heart disease (non-obstructive coronary artery disease and obstructive coronary artery disease)

Cardiovascular research, 2020-03, Vol.116 (4), p.771-786 [Peer Reviewed Journal]

Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2020. For permissions, please email: journals.permissions@oup.com. 2020 ;Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2020. For permissions, please email: journals.permissions@oup.com. ;ISSN: 0008-6363 ;EISSN: 1755-3245 ;DOI: 10.1093/cvr/cvaa005 ;PMID: 31958128

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  • Title:
    Coronary microvascular dysfunction in stable ischaemic heart disease (non-obstructive coronary artery disease and obstructive coronary artery disease)
  • Author: Sechtem, Udo ; Brown, David ; Godo, Shigeo ; Lanza, Gaetano Antonio ; Shimokawa, Hiro ; Sidik, Novalia
  • Is Part Of: Cardiovascular research, 2020-03, Vol.116 (4), p.771-786
  • Description: Abstract Diffuse and focal epicardial coronary disease and coronary microvascular abnormalities may exist side-by-side. Identifying the contributions of each of these three players in the coronary circulation is a difficult task. Yet identifying coronary microvascular dysfunction (CMD) as an additional player in patients with coronary artery disease (CAD) may provide explanations of why symptoms may persist frequently following and why global coronary flow reserve may be more prognostically important than fractional flow reserve measured in a single vessel before percutaneous coronary intervention. This review focuses on the challenges of identifying the presence of CMD in the context of diffuse non-obstructive CAD and obstructive CAD. Furthermore, it is going to discuss the pathophysiology in this complex situation, examine the clinical context in which the interaction of the three components of disease takes place and finally look at non-invasive diagnostic methods relevant for addressing this question.
  • Publisher: England: Oxford University Press
  • Language: English
  • Identifier: ISSN: 0008-6363
    EISSN: 1755-3245
    DOI: 10.1093/cvr/cvaa005
    PMID: 31958128
  • Source: GFMER Free Medical Journals
    Alma/SFX Local Collection

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