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Ambient air pollution and birth defects in brisbane, australia

PloS one, 2009-04, Vol.4 (4), p.e5408 [Peer Reviewed Journal]

COPYRIGHT 2009 Public Library of Science ;2009 Hansen et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;Hansen et al. 2009 ;ISSN: 1932-6203 ;EISSN: 1932-6203 ;DOI: 10.1371/journal.pone.0005408 ;PMID: 19404385

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Title:
Ambient air pollution and birth defects in brisbane, australia
Author: Hansen, Craig A ; Barnett, Adrian G ; Jalaludin, Bin B ; Morgan, Geoffrey G
Pan, Xiaoping
Subjects: Adult ; Air pollution ; Air Pollution - adverse effects ; Air Pollution - analysis ; Air quality ; Air quality assessments ; Aorta ; Atmospheric pollution ; Australia - epidemiology ; Birth ; Birth defects ; Carbon Monoxide - analysis ; Case-Control Studies ; Childbirth & labor ; Cleft Lip - etiology ; Cleft lip/palate ; Cleft Palate - etiology ; Congenital Abnormalities - epidemiology ; Congenital Abnormalities - etiology ; Congenital anomalies ; Congenital defects ; Congenital diseases ; Congenital heart disease ; Dioxins ; Environmental Monitoring ; Environmental pollution ; Environmental protection ; Epidemiological Monitoring ; Female ; Genetic disorders ; Health aspects ; Health services ; Heart ; Heart Defects, Congenital - etiology ; Heart diseases ; Humans ; Infant mortality ; Infant, Newborn ; Infants ; Logistic Models ; Marital status ; Mothers ; Neonates ; Nitrogen dioxide ; Nitrogen Dioxide - analysis ; Outdoor air quality ; Ozone - analysis ; Patient outcomes ; Pollutants ; Pollution ; Pollution levels ; Pregnancy ; Public health ; Public Health and Epidemiology ; Public Health and Epidemiology/Environmental Health ; Public Health and Epidemiology/Epidemiology ; Pulmonary artery ; Regression analysis ; Risk ; Studies ; Sulfur dioxide ; Young Adult
Is Part Of: PloS one, 2009-04, Vol.4 (4), p.e5408
Description: Birth defects are a major public health concern as they are the leading cause of neonatal and infant mortality. Observational studies have linked environmental pollution to adverse birth outcomes, including congenital anomalies. This study examined potential associations between ambient air pollution and congenital heart defects and cleft lip or palate among births in Brisbane, Australia (1998-2004). Ambient air pollution levels were averaged over weeks 3-8 of pregnancy among 150,308 births. Using a case-control design, we used conditional logistic regression and matched cases to 5 controls. Analyses were conducted using all births, and then births where the mother resided within 6 and 12 kilometers of an ambient air quality monitor. When analyzing all births there was no indication that ambient air pollution in Brisbane was associated with a higher risk of cardiac defects. Among births where the mother resided within 6 kilometers of an ambient air quality monitor, a 5 ppb increase in O(3) was associated with an increased risk of pulmonary artery and valve defects (OR 2.96, 95% CI: 1.34, 7.52) while a 0.6 ppb increase in SO(2) was associated with an increased risk of aortic artery and valve defects (OR 10.76, 95% CI: 1.50, 179.8). For oral cleft defects among all births, the only adverse association was between SO(2) and cleft lip with or without cleft palate (OR 1.27, 95% CI: 1.01, 1.62). However, various significant inverse associations were also found between air pollutants and birth defects. This study found mixed results and it is difficult to conclude whether ambient air pollution in Brisbane has an adverse association with the birth defects examined. Studies using more detailed estimates of air pollution exposure are needed.
Publisher: United States: Public Library of Science
Language: English
Identifier: ISSN: 1932-6203
EISSN: 1932-6203
DOI: 10.1371/journal.pone.0005408
PMID: 19404385
Source: Public Library of Science (PLoS) Journals Open Access
GFMER Free Medical Journals
MEDLINE
PubMed Central
ProQuest Central
DOAJ Directory of Open Access Journals

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Ambient air pollution and birth defects in brisbane, australia

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