Language:

Outcomes of extremely low birth weight infants with bronchopulmonary dysplasia: impact of the physiologic definition

Early human development, 2012-07, Vol.88 (7), p.509 [Peer Reviewed Journal]

Copyright © 2012 Elsevier Ltd. All rights reserved. ;EISSN: 1872-6232 ;DOI: 10.1016/j.earlhumdev.2011.12.013 ;PMID: 22236557

Digital Resources/Online E-Resources

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
Outcomes of extremely low birth weight infants with bronchopulmonary dysplasia: impact of the physiologic definition
Author: Natarajan, Girija ; Pappas, Athina ; Shankaran, Seetha ; Kendrick, Douglas E ; Das, Abhik ; Higgins, Rosemary D ; Laptook, Abbot R ; Bell, Edward F ; Stoll, Barbara J ; Newman, Nancy ; Hale, Ellen C ; Bara, Rebecca ; Walsh, Michele C
Subjects: Adult ; Algorithms ; Bronchopulmonary Dysplasia - classification ; Bronchopulmonary Dysplasia - diagnosis ; Bronchopulmonary Dysplasia - physiopathology ; Bronchopulmonary Dysplasia - therapy ; Early Medical Intervention ; Educational Status ; Female ; Follow-Up Studies ; Gestational Age ; Humans ; Infant, Extremely Low Birth Weight - physiology ; Infant, Newborn ; Infant, Newborn, Diseases - classification ; Infant, Newborn, Diseases - diagnosis ; Infant, Newborn, Diseases - physiopathology ; Infant, Newborn, Diseases - therapy ; Male ; Prognosis ; Terminology as Topic ; Treatment Outcome ; Young Adult
Is Part Of: Early human development, 2012-07, Vol.88 (7), p.509
Description: We compared neurodevelopmental outcomes of extremely low birth weight (ELBW) infants with and without bronchopulmonary dysplasia (BPD), using the physiologic definition. ELBW (birth weights<1000 g) infants admitted to the Neonatal Research Network centers and hospitalized at 36 weeks postmenstrual age (n=1189) were classified using the physiologic definition of BPD. Infants underwent Bayley III assessment at 18-22 months corrected age. Multivariable logistic regression was used to determine the association between physiologic BPD and cognitive impairment (score<70). BPD by the physiologic definition was diagnosed in 603 (52%) infants, 537 of whom were mechanically ventilated or on FiO(2)>30% and 66 who failed the room air challenge. Infants on room air (n=505) and those who passed the room air challenge (n=51) were classified as "no BPD" (n=556). At follow up, infants with BPD had significantly lower mean weight and head circumference. Moderate to severe cerebral palsy (7 vs. 2.1%) and spastic diplegia (7.8 vs. 4.1%) and quadriplegia (3.9 vs. 0.9%) phenotypes as well as cognitive (12.8 vs. 4.6%) and language scores<70 (24.2 vs. 12.3%) were significantly more frequent in those with BPD compared to those without BPD. BPD was independently associated (adjusted OR 2.4; 95% CI 1.40-4.13) with cognitive impairment. Rates of adverse neurodevelopmental outcomes in early childhood were significantly higher in those with BPD. BPD by the physiologic definition was independently associated with cognitive impairment using Bayley Scales III. These findings have implications for targeted post-discharge surveillance and early intervention.
Publisher: Ireland
Language: English
Identifier: EISSN: 1872-6232
DOI: 10.1016/j.earlhumdev.2011.12.013
PMID: 22236557
Source: MEDLINE

Back to results list


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

Outcomes of extremely low birth weight infants with bronchopulmonary dysplasia: impact of the physiologic definition

Copyright © 2012 Elsevier Ltd. All rights reserved. ;EISSN: 1872-6232 ;DOI: 10.1016/j.earlhumdev.2011.12.013 ;PMID: 22236557

Searching Remote Databases, Please Wait