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The outcome of ambulatory DVT management using a multidisciplinary approach

Clinical and laboratory haematology, 2001-10, Vol.23 (5), p.301-306 [Peer Reviewed Journal]

2002 INIST-CNRS ;ISSN: 0141-9854 ;EISSN: 1365-2257 ;DOI: 10.1046/j.1365-2257.2001.00403.x ;PMID: 11703412 ;CODEN: CLHAD3

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Title:
The outcome of ambulatory DVT management using a multidisciplinary approach
Author: Rose, P. ; Bell, D. ; Green, E.S. ; Davenport, A. ; Fegan, C. ; Grech, H. ; O'Shaughnessy, D. ; Voke, J.
Subjects: Adolescent ; Adult ; Aged ; Aged, 80 and over ; Ambulatory Care - methods ; Ambulatory Care - standards ; Biological and medical sciences ; Blood. Blood coagulation. Reticuloendothelial system ; Disease Management ; Drug Evaluation ; Economic ; Female ; Fibrinolytic Agents - administration & dosage ; Fibrinolytic Agents - standards ; Fibrinolytic Agents - toxicity ; Hemorrhage - chemically induced ; Heparin, Low-Molecular-Weight - administration & dosage ; Heparin, Low-Molecular-Weight - standards ; Heparin, Low-Molecular-Weight - toxicity ; Hospitalization ; Humans ; low molecular weight heparin ; Male ; Medical sciences ; Middle Aged ; outpatient treatment ; patient outcomes ; Pharmacology. Drug treatments ; Recurrence ; Retrospective Studies ; Survival Rate ; Thromboembolism - etiology ; Treatment Outcome ; venous thromboembolism ; Venous Thrombosis - complications ; Venous Thrombosis - drug therapy ; Venous Thrombosis - mortality
Is Part Of: Clinical and laboratory haematology, 2001-10, Vol.23 (5), p.301-306
Description: Low molecular weight heparins (LMWHs) have been demonstrated to be at least as safe and effective as unfractionated heparin (UFH) in the initial management of deep vein thrombosis (DVT). However, the effectiveness of using LMWH in the ambulatory management of DVT in a ‘real‐life’ setting has yet to be evaluated. This multicentre retrospective study involving 697 patients considers the outcome data of patients under‐ going ambulatory DVT treatment with tinzaparin (Innohep®, Leo Pharmaceuticals, Risborough, Buckinghamshire, UK). During the 6 months following presentation, 17 (2.5%) patients had confirmed thromboembolic complications, of which 14 occurred subsequent to the initial LMWH treatment phase (‘late’). There were no deaths in this group. Bleeding complications were reported in 23 (3.4%) patients, with 13 of these being classified as ‘late’. Of these, two events were considered major resulting in hospitalization and death. Hospitalization for all causes was 6.8% (45 patients) with 32 patients being admitted for thromboembolic or bleeding complications. Overall mortality was 6.7%. These results compare favourably with published clinical trial data. This study demonstrates that ambulatory treatment of proven DVT with LMWH is both safe and effective.
Publisher: Oxford UK: Blackwell Science Ltd
Language: English
Identifier: ISSN: 0141-9854
EISSN: 1365-2257
DOI: 10.1046/j.1365-2257.2001.00403.x
PMID: 11703412
CODEN: CLHAD3
Source: MEDLINE
Alma/SFX Local Collection

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The outcome of ambulatory DVT management using a multidisciplinary approach

2002 INIST-CNRS ;ISSN: 0141-9854 ;EISSN: 1365-2257 ;DOI: 10.1046/j.1365-2257.2001.00403.x ;PMID: 11703412 ;CODEN: CLHAD3

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