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Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

Nature (London), 2011-10, Vol.478 (7367), p.103-109 [Peer Reviewed Journal]

2015 INIST-CNRS ;COPYRIGHT 2011 Nature Publishing Group ;COPYRIGHT 2011 Nature Publishing Group ;Copyright Nature Publishing Group Oct 6, 2011 ;Distributed under a Creative Commons Attribution 4.0 International License ;ISSN: 0028-0836 ;ISSN: 1476-4687 ;EISSN: 1476-4687 ;DOI: 10.1038/nature10405 ;PMID: 21909115 ;CODEN: NATUAS

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Title:
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk
Author: Munroe, Patricia B ; Smith, Albert V ; Verwoert, Germaine C ; Amin, Najaf ; Teumer, Alexander ; Zhao, Jing Hua ; Parsa, Afshin ; Dehghan, Abbas ; Peden, John F ; Rudan, Igor ; Chambers, John C ; Fox, Ervin R ; Alexander, Myriam ; Tabara, Yasuharu ; Seielstad, Mark ; Kuznetsova, Tatiana ; Ludwig, Barbara ; Tomaszewski, Maciej ; O'Connell, Jeffrey R ; Kardia, Sharon L ; Hingorani, Aroon D ; Lawlor, Debbie A ; Lawrence, Robert W ; Clarke, Robert ; Ongen, Halit ; Li, Yali ; Adair, Linda S ; Lee, Nanette R ; Bolton, Judith A Hoffman ; Chaturvedi, Nish ; Islam, Muhammad ; Kulkarni, Smita R ; Groop, Leif ; Voight, Benjamin F ; Guarrera, Simonetta ; Plump, Andrew ; Barroso, Inês ; Vartiainen, Erkki ; Burton, Paul R ; Dong, Yanbin ; Wang, Xiaoling ; Lohman, Kurt K ; Smith, Nicholas L ; Kinra, Sanjay ; Prabhakaran, Dorairaj ; Forrester, Terrence ; Hilton, Gina ; McKenzie, Colin A ; Kita, Yoshikuni ; Wichmann, H-Erich ; Zhang, Weihua ; Hedblad, Bo ; Nilsson, Peter ; Wong, Andrew ; Raffel, Leslie J ; Yao, Jie ; Schwartz, Stephen M ; Ikram, M Arfan ; Rasheed, Asif ; Watkins, Hugh ; Bakker, Stephan J L ; van Gilst, Wiek H ; Janipalli, Charles S ; Rivadeneira, Fernando ; Ala-Korpela, Mika ; Soininen, Pasi ; Völzke, Henry ; Lathrop, Mark ; Zelenika, Diana ; Deloukas, Panos ; Mangino, Massimo ; Zhai, Guangju ; Nalls, Michael A ; Terzic, Janos ; Kumar, M V Kranthi ; Charchar, Fadi J ; Schwarz, Peter E H ; Guo, Xiuqing ; Bots, Michiel L ; Samani, Nilesh J ; Palmer, Lyle J ; Casas, Juan P ; Vineis, Paolo ; Raitakari, Olli ; Wong, Tien Y ; Tai, E Shyong ; Cooper, Richard S ; Rao, Dabeeru C ; Harris, Tamara B ; Morris, Richard W ; Kivimaki, Mika ; Coresh, Josef ; Navis, Gerjan ; Han, Bok-Ghee ; Melander, Olle ; Gyllensten, Ulf B ; Rettig, Rainer ; Uda, Manuela ; Psaty, Bruce M ; Abecasis, Gonçalo R
Subjects: Africa - ethnology ; Annan klinisk medicin ; Asia - ethnology ; Biological and medical sciences ; Blood Pressure - genetics ; Blood Pressure - physiology ; Cardiac and Cardiovascular Systems ; Cardiovascular disease ; Cardiovascular diseases ; Cardiovascular Diseases - genetics ; Clinical Medicine ; Confidence intervals ; Coronary Artery Disease - genetics ; Disease ; Europe - ethnology ; Fundamental and applied biological sciences. Psychology ; Genealogy ; Genetic aspects ; Genetic Predisposition to Disease - genetics ; Genetics ; Genetics and genomics ; Genetics of eukaryotes. Biological and molecular evolution ; Genome-Wide Association Study ; Genomes ; Health and medicine ; Human ; Humans ; Hypertension ; Hypertension - genetics ; Independent sample ; Kardiologi ; Kidney Diseases - genetics ; Klinisk medicin ; Life Sciences ; MEDICAL AND HEALTH SCIENCES ; MEDICIN OCH HÄLSOVETENSKAP ; Other Clinical Medicine ; Polymorphism, Single Nucleotide - genetics ; Population genetics, reproduction patterns ; Prevention ; Risk factors ; Single nucleotide polymorphisms ; Standard deviation ; Stroke - genetics
Is Part Of: Nature (London), 2011-10, Vol.478 (7367), p.103-109
Description: Blood pressure is a heritable trait influenced by several biological pathways and responsive to environmental stimuli. Over one billion people worldwide have hypertension (≥140 mm Hg systolic blood pressure or ≥90 mm Hg diastolic blood pressure). Even small increments in blood pressure are associated with an increased risk of cardiovascular events. This genome-wide association study of systolic and diastolic blood pressure, which used a multi-stage design in 200,000 individuals of European descent, identified sixteen novel loci: six of these loci contain genes previously known or suspected to regulate blood pressure (GUCY1A3-GUCY1B3, NPR3-C5orf23, ADM, FURIN-FES, GOSR2, GNAS-EDN3); the other ten provide new clues to blood pressure physiology. A genetic risk score based on 29 genome-wide significant variants was associated with hypertension, left ventricular wall thickness, stroke and coronary artery disease, but not kidney disease or kidney function. We also observed associations with blood pressure in East Asian, South Asian and African ancestry individuals. Our findings provide new insights into the genetics and biology of blood pressure, and suggest potential novel therapeutic pathways for cardiovascular disease prevention.
Publisher: London: Nature Publishing Group
Language: English
Identifier: ISSN: 0028-0836
ISSN: 1476-4687
EISSN: 1476-4687
DOI: 10.1038/nature10405
PMID: 21909115
CODEN: NATUAS
Source: ProQuest One Psychology
MEDLINE
Alma/SFX Local Collection
SWEPUB Freely available online
ProQuest Central

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Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

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