Language:

Identification of Kudoa septempunctata as the Causative Agent of Novel Food Poisoning Outbreaks in Japan by Consumption of Paralichthys olivaceus in Raw Fish

Clinical infectious diseases, 2012-04, Vol.54 (8), p.1046-1052 [Peer Reviewed Journal]

Copyright © 2012 Oxford University Press on behalf of the Infectious Diseases Society of America ;The Author 2012. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com. 2012 ;2015 INIST-CNRS ;ISSN: 1058-4838 ;EISSN: 1537-6591 ;DOI: 10.1093/cid/cir1040 ;PMID: 22281845 ;CODEN: CIDIEL

Full text available

Citations Cited by

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
Identification of Kudoa septempunctata as the Causative Agent of Novel Food Poisoning Outbreaks in Japan by Consumption of Paralichthys olivaceus in Raw Fish
Author: Kawai, Takao ; Sekizuka, Tsuyoshi ; Yahata, Yuichiro ; Kuroda, Makoto ; Kumeda, Yuko ; Iijima, Yoshio ; Kamata, Yoichi ; Sugita-Konishi, Yoshiko ; Ohnishi, Takahiro
Subjects: Animals ; ARTICLES AND COMMENTARIES ; Bacteria ; Biological and medical sciences ; Chemicals ; Complementary DNA ; Diarrhea - diagnosis ; Diarrhea - etiology ; Diet ; Disease Models, Animal ; Disease Outbreaks ; DNA ; Epidemics ; Epidemiology ; Feeding Behavior ; Female ; Fish ; Flatfishes - parasitology ; Food contamination ; Food contamination & poisoning ; Food-borne diseases ; Foodborne Diseases - diagnosis ; Foodborne Diseases - parasitology ; Foodborne illnesses ; Housing ; Humans ; Infectious diseases ; Japan ; Kudoa ; Male ; Medical sciences ; Metagenome ; Mice ; Microscopy ; Myxozoa - isolation & purification ; Outbreaks ; Paralichthys olivaceus ; Parasitic Diseases - diagnosis ; Parasitic Diseases - parasitology ; Pleuronectiformes ; Polymerase chain reaction ; Raw fish ; Real-Time Polymerase Chain Reaction ; Residential areas ; Sequence Analysis, DNA ; Sequencing ; Shrews ; Spores ; Toxins ; Viruses ; Vomiting ; Vomiting - diagnosis ; Vomiting - etiology
Is Part Of: Clinical infectious diseases, 2012-04, Vol.54 (8), p.1046-1052
Description: Background. Outbreaks of an unidentified food-borne illness associated with the consumption of raw fish have increased in Japan since 2003. Those affected with this illness develop diarrhea and emesis within 2—20 hours after a meal including raw fish. No known causative agents such as bacteria, viruses, bacterial toxins, or toxic chemicals have been detected in the foods that were ingested. Fortunately, this illness is self-limiting with good prognosis in all cases. Methods. We conducted an epidemiological analysis of outbreaks that occurred during 2008 and 2010 and analysed a fish sample from one outbreak by metagenomic DNA sequencing, real-time polymerase chain reaction, and direct microscopic observations. The pathogenicity of a putative risk factor identified by these techniques was assessed using the suckling-mouse test and a house musk shrew emetic assay. Results. The epidemiological analysis of outbreaks in 24 municipalities involving >1300 subjects implicated an olive flounder (Paralichthys olivaceus) as the causative food source. The presence of Kudoa septempunctata, a recently-described myxosporean species in P. olivaceus, was prevalent in the causative foods. K. septempunctata induced watery stools and an elevated fluid accumulation ratio in suckling mice, as well as vomiting in house musk shrews. Conclusions. These results identify K. septempunctata as the etiological agent of this novel food-borne illness outbreak associated with consumption of raw P. olivaceus. This is the first report, to our knowledge, demonstrating the human pathogenicity of Kudoa spores.
Publisher: Oxford: Oxford University Press
Language: English
Identifier: ISSN: 1058-4838
EISSN: 1537-6591
DOI: 10.1093/cid/cir1040
PMID: 22281845
CODEN: CIDIEL
Source: MEDLINE
Alma/SFX Local Collection

Back to results list


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

Identification of Kudoa septempunctata as the Causative Agent of Novel Food Poisoning Outbreaks in Japan by Consumption of Paralichthys olivaceus in Raw Fish

Searching Remote Databases, Please Wait