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Maternal exposure to criteria air pollutants and congenital heart defects in offspring: results from the national birth defects prevention study

Environmental health perspectives, 2014-08, Vol.122 (8), p.863-872 [Peer Reviewed Journal]

Copyright National Institute of Environmental Health Sciences Aug 2014 ;ISSN: 0091-6765 ;EISSN: 1552-9924 ;DOI: 10.1289/ehp.1307289 ;PMID: 24727555

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Title:
Maternal exposure to criteria air pollutants and congenital heart defects in offspring: results from the national birth defects prevention study
Author: Stingone, Jeanette A ; Luben, Thomas J ; Daniels, Julie L ; Fuentes, Montserrat ; Richardson, David B ; Aylsworth, Arthur S ; Herring, Amy H ; Anderka, Marlene ; Botto, Lorenzo ; Correa, Adolfo ; Gilboa, Suzanne M ; Langlois, Peter H ; Mosley, Bridget ; Shaw, Gary M ; Siffel, Csaba ; Olshan, Andrew F
Subjects: Air Pollutants ; Air pollution ; Bias ; Birth defects ; Children's Health ; Criteria ; Defects ; Exposure ; Female ; Heart ; Heart Defects, Congenital - epidemiology ; Heart Defects, Congenital - etiology ; Humans ; Maternal Exposure - adverse effects ; Medical records ; Nitrogen dioxide ; Nitrogen Dioxide - toxicity ; Outdoor air quality ; Ozone - toxicity ; Particulate Matter - toxicity ; Pollutants ; Population ; Pregnancy ; Studies ; Sulfur Dioxide - toxicity
Is Part Of: Environmental health perspectives, 2014-08, Vol.122 (8), p.863-872
Description: Epidemiologic literature suggests that exposure to air pollutants is associated with fetal development. We investigated maternal exposures to air pollutants during weeks 2-8 of pregnancy and their associations with congenital heart defects. Mothers from the National Birth Defects Prevention Study, a nine-state case-control study, were assigned 1-week and 7-week averages of daily maximum concentrations of carbon monoxide, nitrogen dioxide, ozone, and sulfur dioxide and 24-hr measurements of fine and coarse particulate matter using the closest air monitor within 50 km to their residence during early pregnancy. Depending on the pollutant, a maximum of 4,632 live-birth controls and 3,328 live-birth, fetal-death, or electively terminated cases had exposure data. Hierarchical regression models, adjusted for maternal demographics and tobacco and alcohol use, were constructed. Principal component analysis was used to assess these relationships in a multipollutant context. Positive associations were observed between exposure to nitrogen dioxide and coarctation of the aorta and pulmonary valve stenosis. Exposure to fine particulate matter was positively associated with hypoplastic left heart syndrome but inversely associated with atrial septal defects. Examining individual exposure-weeks suggested associations between pollutants and defects that were not observed using the 7-week average. Associations between left ventricular outflow tract obstructions and nitrogen dioxide and between hypoplastic left heart syndrome and particulate matter were supported by findings from the multipollutant analyses, although estimates were attenuated at the highest exposure levels. Using daily maximum pollutant levels and exploring individual exposure-weeks revealed some positive associations between certain pollutants and defects and suggested potential windows of susceptibility during pregnancy.
Publisher: United States: National Institute of Environmental Health Sciences
Language: English
Identifier: ISSN: 0091-6765
EISSN: 1552-9924
DOI: 10.1289/ehp.1307289
PMID: 24727555
Source: U.S. Government Documents
MEDLINE
PubMed Central
ProQuest Central
DOAJ Directory of Open Access Journals

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Maternal exposure to criteria air pollutants and congenital heart defects in offspring: results from the national birth defects prevention study

Copyright National Institute of Environmental Health Sciences Aug 2014 ;ISSN: 0091-6765 ;EISSN: 1552-9924 ;DOI: 10.1289/ehp.1307289 ;PMID: 24727555

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