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DNA analysis of an early modern human from Tianyuan Cave, China

Proceedings of the National Academy of Sciences - PNAS, 2013-02, Vol.110 (6), p.2223-2227 [Peer Reviewed Journal]

copyright © 1993-2008 National Academy of Sciences of the United States of America ;Copyright National Academy of Sciences Feb 5, 2013 ;ISSN: 0027-8424 ;EISSN: 1091-6490 ;DOI: 10.1073/pnas.1221359110 ;PMID: 23341637

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Title:
DNA analysis of an early modern human from Tianyuan Cave, China
Author: Fu, Qiaomei ; Meyer, Matthias ; Gao, Xing ; Stenzel, Udo ; Burbano, Hernán A. ; Kelso, Janet ; Pääbo, Svante
Subjects: Animals ; Asian Continental Ancestry Group - genetics ; Asian Continental Ancestry Group - history ; Base Sequence ; Biological Sciences ; Caves ; China ; Chromosomes ; Chromosomes, Human, Pair 21 - genetics ; DNA ; DNA probes ; DNA, Mitochondrial - genetics ; DNA, Mitochondrial - history ; DNA, Mitochondrial - isolation & purification ; Fossils ; Gene Library ; Genetics, Population ; Genomes ; History, Ancient ; Hominidae - genetics ; Hominids ; Human genetics ; Humans ; Libraries ; Mitochondrial DNA ; Molecular Sequence Data ; Morphology ; Nucleotide sequences ; Phylogeny ; Phylogeography ; Polymorphism ; Sequence Analysis, DNA ; Sequence Homology, Nucleic Acid ; Sequencing
Is Part Of: Proceedings of the National Academy of Sciences - PNAS, 2013-02, Vol.110 (6), p.2223-2227
Description: Hominins with morphology similar to present-day humans appear in the fossil record across Eurasia between 40,000 and 50,000 y ago. The genetic relationships between these early modern humans and present-day human populations have not been established. We have extracted DNA from a 40,000-y-old anatomically modern human from Tianyuan Cave outside Beijing, China. Using a highly scalable hybridization enrichment strategy, we determined the DNA sequences of the mitochondrial genome, the entire nonrepetitive portion of chromosome 21 (∼30 Mbp), and over 3,000 polymorphic sites across the nuclear genome of this individual. The nuclear DNA sequences determined from this early modern human reveal that the Tianyuan individual derived from a population that was ancestral to many present-day Asians and Native Americans but postdated the divergence of Asians from Europeans. They also show that this individual carried proportions of DNA variants derived from archaic humans similar to present-day people in mainland Asia.
Publisher: United States: National Academy of Sciences
Language: English
Identifier: ISSN: 0027-8424
EISSN: 1091-6490
DOI: 10.1073/pnas.1221359110
PMID: 23341637
Source: Geneva Foundation Free Medical Journals at publisher websites
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DNA analysis of an early modern human from Tianyuan Cave, China

copyright © 1993-2008 National Academy of Sciences of the United States of America ;Copyright National Academy of Sciences Feb 5, 2013 ;ISSN: 0027-8424 ;EISSN: 1091-6490 ;DOI: 10.1073/pnas.1221359110 ;PMID: 23341637

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