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The ErbB signaling network in embryogenesis and oncogenesis: signal diversification through combinatorial ligand-receptor interactions

FEBS Letters, 1997-06, Vol.410 (1), p.83-86 [Peer Reviewed Journal]

1997 Federation of European Biochemical Societies ;FEBS Letters 410 (1997) 1873-3468 © 2015 Federation of European Biochemical Societies ;ISSN: 0014-5793 ;EISSN: 1873-3468 ;DOI: 10.1016/S0014-5793(97)00412-2 ;PMID: 9247128

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Title:
The ErbB signaling network in embryogenesis and oncogenesis: signal diversification through combinatorial ligand-receptor interactions
Author: Alroy, Iris ; Yarden, Yosef
Subjects: Animals ; Cell Transformation, Neoplastic ; Embryonic and Fetal Development - physiology ; Epidermal Growth Factor - metabolism ; ErbB ; ErbB Receptors - metabolism ; Growth factor ; Humans ; Ligands ; Proto-Oncogene Proteins - metabolism ; Receptor ; Receptor, ErbB-2 - metabolism ; Receptor, ErbB-3 ; Receptor, ErbB-4 ; Signal Transduction ; Tyrosine kinase
Is Part Of: FEBS Letters, 1997-06, Vol.410 (1), p.83-86
Description: Ligand-induced activation of receptor tyrosine kinases (RTK) results in the initiation of diverse cellular pathways, including proliferation, differentiation and cell migration. The ErbB family of RTKs represents a model for signal diversification through the formation of homo- and heterodimeric receptor complexes. Each dimeric receptor complex will initiate a distinct signaling pathway by recruiting a different set of Src homology 2- (SH2-) containing effector proteins. Further complexity is added due to the existence of an oncogenic receptor that enhances and stabilizes dimerization but has no ligand (ErbB-2), and a receptor that can recruit novel SH-2-containing proteins, but is itself devoid of kinase activity (ErbB-3). The resulting signaling network has important implications for embryonic development and malignant transformation.
Publisher: England: Elsevier B.V
Language: English
Identifier: ISSN: 0014-5793
EISSN: 1873-3468
DOI: 10.1016/S0014-5793(97)00412-2
PMID: 9247128
Source: Geneva Foundation Free Medical Journals at publisher websites
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The ErbB signaling network in embryogenesis and oncogenesis: signal diversification through combinatorial ligand-receptor interactions

1997 Federation of European Biochemical Societies ;FEBS Letters 410 (1997) 1873-3468 © 2015 Federation of European Biochemical Societies ;ISSN: 0014-5793 ;EISSN: 1873-3468 ;DOI: 10.1016/S0014-5793(97)00412-2 ;PMID: 9247128

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