Language:

Essential role for ERK2 mitogen‐activated protein kinase in placental development

Genes to cells : devoted to molecular & cellular mechanisms, 2003-11, Vol.8 (11), p.847-856 [Peer Reviewed Journal]

ISSN: 1356-9597 ;EISSN: 1365-2443 ;DOI: 10.1046/j.1365-2443.2003.00680.x ;PMID: 14622137

Full text available

Citations Cited by

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
Essential role for ERK2 mitogen‐activated protein kinase in placental development
Author: Hatano, Naoya ; Mori, Yoshiko ; Oh‐hora, Masatsugu ; Kosugi, Atsushi ; Fujikawa, Takahiko ; Nakai, Naoya ; Niwa, Hitoshi ; Miyazaki, Jun–ichi ; Hamaoka, Toshiyuki ; Ogata, Masato
Subjects: Animals ; Embryonic and Fetal Development - physiology ; Female ; Gene Deletion ; Genes, Lethal ; Immunoblotting ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mice, Transgenic ; Mitogen-Activated Protein Kinase 1 - physiology ; Neovascularization, Physiologic - physiology ; Placenta - blood supply ; Placenta - embryology ; Pregnancy ; Reverse Transcriptase Polymerase Chain Reaction ; Transfection ; Trophoblasts - cytology ; Trophoblasts - metabolism
Is Part Of: Genes to cells : devoted to molecular & cellular mechanisms, 2003-11, Vol.8 (11), p.847-856
Description: Background: Extracellular signal‐regulated kinase 2 (ERK2) has been implicated in cell proliferation, differentiation, and survival. However, its role in vivo remains to be determined. Results: Here we show that the targeted disruption of the mouse ERK2 gene results in embryonic lethality by E11.5 and severe abnormality of the placenta. In these animals, the labyrinthine layer of the placenta is very thin and few foetal blood vessels are observed. ERK2 mutants can be rescued by the transgenic expression of ERK2, demonstrating that these abnormalities are caused by ERK2‐deficiency. Although ERK2‐deficient fetuses are much smaller than wild‐type littermates, this seems to be secondary to malfunction of the placenta. When the placental defect is rescued by tetraploid‐aggregation, ERK2‐deficient foetuses grow as well as littermate controls. Conclusion: These observations indicate that ERK2 is essential for placental development and suggest that ERK2 in the trophoblast compartment may be indispensable for the vascularization of the labyrinth.
Publisher: Oxford, UK: Blackwell Science Ltd
Language: English
Identifier: ISSN: 1356-9597
EISSN: 1365-2443
DOI: 10.1046/j.1365-2443.2003.00680.x
PMID: 14622137
Source: GFMER Free Medical Journals
MEDLINE
Freely Accessible Japanese Titles

Back to results list


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

Essential role for ERK2 mitogen‐activated protein kinase in placental development

ISSN: 1356-9597 ;EISSN: 1365-2443 ;DOI: 10.1046/j.1365-2443.2003.00680.x ;PMID: 14622137

Searching Remote Databases, Please Wait