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Timing of Initiation of Antiretroviral Drugs during Tuberculosis Therapy

The New England journal of medicine, 2010-02, Vol.362 (8), p.697-706 [Tạp chí có phản biện]

Copyright © 2010 Massachusetts Medical Society. All rights reserved. ;2015 INIST-CNRS ;2010 Massachusetts Medical Society ;ISSN: 0028-4793 ;EISSN: 1533-4406 ;DOI: 10.1056/NEJMoa0905848 ;PMID: 20181971 ;CODEN: NEJMAG

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Nhan đề:
Timing of Initiation of Antiretroviral Drugs during Tuberculosis Therapy
Tác giả: Abdool Karim, Quarraisha ; Abdool Karim, Salim S ; Naidoo, Kogieleum ; Grobler, Anneke ; Padayatchi, Nesri ; Baxter, Cheryl ; Gray, Andrew ; Gengiah, Tanuja ; Nair, Gonasagrie ; Bamber, Sheila ; Singh, Aarthi ; Khan, Munira ; Pienaar, Jacqueline ; El-Sadr, Wafaa ; Friedland, Gerald
Chủ đề: Adult ; AIDS-Related Opportunistic Infections - drug therapy ; AIDS-Related Opportunistic Infections - mortality ; Anti-Retroviral Agents - administration & dosage ; Anti-Retroviral Agents - adverse effects ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antiretroviral drugs ; Antitubercular Agents - administration & dosage ; Antitubercular Agents - adverse effects ; Antiviral agents ; Biological and medical sciences ; Care and treatment ; CD4 Lymphocyte Count ; Drug Administration Schedule ; Drug therapy ; Drug Therapy, Combination ; Fatalities ; Female ; Follow-Up Studies ; General aspects ; Health aspects ; HIV ; HIV - genetics ; HIV - isolation & purification ; HIV Infections - complications ; HIV Infections - drug therapy ; HIV Infections - mortality ; Human immunodeficiency virus ; Human viral diseases ; Humans ; Infections ; Infectious diseases ; Kaplan-Meier Estimate ; Male ; Medical sciences ; Middle Aged ; Patient Compliance - statistics & numerical data ; Pharmacology. Drug treatments ; RNA, Viral - blood ; Tuberculosis ; Tuberculosis - drug therapy ; Tuberculosis - mortality ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids ; Viral Load ; Young Adult
Là 1 phần của: The New England journal of medicine, 2010-02, Vol.362 (8), p.697-706
Mô tả: The optimal timing for the initiation of antiretroviral therapy in patients with both human immunodeficiency virus infection and tuberculosis is unclear. This open-label study involves 642 such patients who received antiretroviral therapy initiated either during or after the completion of tuberculosis therapy. The initiation of antiretroviral therapy during tuberculosis therapy was associated with a relative reduction of 56% in the rate of death. In patients with both HIV and tuberculosis, the initiation of antiretroviral therapy during tuberculosis therapy was associated with a relative reduction of 56% in the rate of death. In 2007, it was estimated that there were about 33 million persons living with human immunodeficiency virus (HIV) infection 1 and 9.2 million persons with newly diagnosed tuberculosis worldwide. 2 The two diseases are closely intertwined, and the number of patients with coinfection continues to grow rapidly. 3 Tuberculosis is the most common opportunistic disease 4 and the most common cause of death in patients with HIV infection in developing countries. 5 Notwithstanding effective tuberculosis chemotherapy, in the presence of HIV infection, tuberculosis is associated with substantially increased case fatality rates 6 and is also the most commonly reported cause of death in South Africa. 7 In . . .
Nơi xuất bản: Waltham, MA: Massachusetts Medical Society
Ngôn ngữ: English;German
Số nhận dạng: ISSN: 0028-4793
EISSN: 1533-4406
DOI: 10.1056/NEJMoa0905848
PMID: 20181971
CODEN: NEJMAG
Nguồn: ProQuest One Psychology
MEDLINE
Alma/SFX Local Collection
ProQuest Central

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Timing of Initiation of Antiretroviral Drugs during Tuberculosis Therapy

Copyright © 2010 Massachusetts Medical Society. All rights reserved. ;2015 INIST-CNRS ;2010 Massachusetts Medical Society ;ISSN: 0028-4793 ;EISSN: 1533-4406 ;DOI: 10.1056/NEJMoa0905848 ;PMID: 20181971 ;CODEN: NEJMAG

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