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Associations between Vocal Symptoms and Genetic Variants in the Oxytocin Receptor and Arginine Vasopressin 1A Receptor Gene

Journal of speech, language, and hearing research, 2017-07, Vol.60 (7), p.1843-1854 [Peer Reviewed Journal]

COPYRIGHT 2017 American Speech-Language-Hearing Association ;COPYRIGHT 2017 American Speech-Language-Hearing Association ;Copyright American Speech-Language-Hearing Association Jul 2017 ;info:eu-repo/semantics/openAccess ;ISSN: 1092-4388 ;EISSN: 1558-9102 ;DOI: 10.1044/2016_JSLHR-S-16-0059 ;PMID: 28687839

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Title:
Associations between Vocal Symptoms and Genetic Variants in the Oxytocin Receptor and Arginine Vasopressin 1A Receptor Gene
Author: Jämsen, Sofia Holmqvist ; Johansson, Ada ; Westberg, Lars ; Santtila, Pekka ; von der Pahlen, Bettina ; Simberg, Susanna
Subjects: Adrenal glands ; aggressive-behavior ; Audiology & Speech-Language Pathology ; Autism ; brain oxytocin ; Correlation ; Female ; Finland ; Finnish language ; Foreign Countries ; Genes ; Genetic aspects ; Genetic Predisposition to Disease ; Genetics ; Genotyping Techniques ; Health aspects ; Hormones ; Humans ; Hydrocortisone - metabolism ; Linguistics ; Male ; Mediation ; mental-health ; Metabolism ; Neurosciences ; Neurovetenskaper ; Observations ; Oto-rino-laryngologi ; Otorhinolaryngology ; oxtr polymorphisms ; Oxytocin ; Physiology ; pituitary-adrenocortical axis ; Polymorphism, Single Nucleotide ; Questionnaires ; Receptors, Oxytocin - genetics ; Receptors, Vasopressin - genetics ; Rehabilitation ; Risk factors ; Rodents ; Saliva - metabolism ; Single nucleotide polymorphisms ; Social support ; social-behavior ; spectrum disorders ; stress reactivity ; Stress response ; Stress Variables ; Studies ; Surveys and Questionnaires ; Symptoms (Individual Disorders) ; Twins ; Vasopressin ; Vasopressins ; Voice Disorders ; Voice Disorders - genetics ; Voice Disorders - metabolism
Is Part Of: Journal of speech, language, and hearing research, 2017-07, Vol.60 (7), p.1843-1854
Description: Purpose: Oxytocin and arginine vasopressin are associated with different aspects of the stress response. As stress is regarded as a risk factor for vocal symptoms, we wanted to explore the association between the oxytocin receptor gene ("OXTR") and arginine vasopressin 1A receptor gene ("AVPR1A") single-nucleotide polymorphisms (SNPs) and vocal symptoms. We also wanted to explore whether such effects might be mediated by cortisol because oxytocin and vasopressin are associated with cortisol levels. Method: A population-based sample (N = 657) of Finnish twins (born 1961-1989) completed a web questionnaire on the occurrence of vocal symptoms. A total of 170 participants submitted saliva samples for hormone analysis. A total of 20 "OXTR" and "AVPR1A" SNPs were analyzed. Results: Three "OXTR" polymorphisms (rs2270465, rs2268493, rs7632287) and 2 "AVPR1A" polymorphisms (rs1587097, rs1042615) showed nominal effects (p < 0.05) on vocal symptoms, of which 1 (rs1587097) remained significant after correcting for multiple testing (p = 0.003). We found potential mediation of the effect of the "OXTR" rs2268493 polymorphism on vocal symptoms through levels of cortisol. Conclusions: The associations between variants of "OXTR" and "AVPR1A" and vocal symptoms indicate that oxytocin and vasopressin might influence vocal symptoms. The effect of oxytocin seems to be partly mediated through cortisol actions.
Publisher: United States: American Speech-Language-Hearing Association
Language: English;Norwegian
Identifier: ISSN: 1092-4388
EISSN: 1558-9102
DOI: 10.1044/2016_JSLHR-S-16-0059
PMID: 28687839
Source: ProQuest One Psychology
Education Resources Information Center (ERIC)
MEDLINE
NORA Norwegian Open Research Archives
Alma/SFX Local Collection
ProQuest Central

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Associations between Vocal Symptoms and Genetic Variants in the Oxytocin Receptor and Arginine Vasopressin 1A Receptor Gene

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