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Brief Report: Cannabidiol-Rich Cannabis in Children with Autism Spectrum Disorder and Severe Behavioral Problems—A Retrospective Feasibility Study

Journal of autism and developmental disorders, 2019-03, Vol.49 (3), p.1284-1288 [Peer Reviewed Journal]

Springer Science+Business Media, LLC, part of Springer Nature 2018 ;COPYRIGHT 2019 Springer ;Journal of Autism and Developmental Disorders is a copyright of Springer, (2018). All Rights Reserved. ;ISSN: 0162-3257 ;EISSN: 1573-3432 ;DOI: 10.1007/s10803-018-3808-2 ;PMID: 30382443

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Title:
Brief Report: Cannabidiol-Rich Cannabis in Children with Autism Spectrum Disorder and Severe Behavioral Problems—A Retrospective Feasibility Study
Author: Aran, Adi ; Cassuto, Hanoch ; Lubotzky, Asael ; Wattad, Nadia ; Hazan, Esther
Subjects: Adolescent ; Analysis ; Appetite ; Appetite loss ; Autism ; Autism Spectrum Disorder - drug therapy ; Autism Spectrum Disorder - psychology ; Autistic children ; Behavior Problems ; Behavioral Science and Psychology ; Behaviour disordered children ; Behavioural problems ; Brief Report ; Cannabidiol - therapeutic use ; Cannabinoids ; Cannabis ; Caregivers ; Child ; Child and School Psychology ; Child behavior ; Child health ; Child, Preschool ; Children ; Clinical trials ; Critical incidents ; Dosage and administration ; Drug Therapy ; Eating Habits ; Efficacy ; Feasibility ; Feasibility Studies ; Female ; Humans ; Irritability ; Male ; Marijuana ; Medical Marijuana - therapeutic use ; Neuroleptics ; Neurosciences ; Outbreaks ; Outcomes of Treatment ; Parent Attitudes ; Patients ; Pediatric research ; Pediatrics ; Pervasive Developmental Disorders ; Problem Behavior - psychology ; Psychological aspects ; Psychology ; Psychoses ; Psychosis ; Public Health ; Retrospective Studies ; Risk factors ; Sleep ; Sleep problems ; Tetrahydrocannabinol ; Treatment Outcome
Is Part Of: Journal of autism and developmental disorders, 2019-03, Vol.49 (3), p.1284-1288
Description: Anecdotal evidence of successful cannabis treatment in autism spectrum disorder (ASD) are accumulating but clinical studies are lacking. This retrospective study assessed tolerability and efficacy of cannabidiol-rich cannabis, in 60 children with ASD and severe behavioral problems (age = 11.8 ± 3.5, range 5.0–17.5; 77% low functioning; 83% boys). Efficacy was assessed using the Caregiver Global Impression of Change scale. Adverse events included sleep disturbances (14%) irritability (9%) and loss of appetite (9%). One girl who used higher tetrahydrocannabinol had a transient serious psychotic event which required treatment with an antipsychotic. Following the cannabis treatment, behavioral outbreaks were much improved or very much improved in 61% of patients. This preliminary study supports feasibility of CBD-based cannabis trials in children with ASD.
Publisher: New York: Springer US
Language: English
Identifier: ISSN: 0162-3257
EISSN: 1573-3432
DOI: 10.1007/s10803-018-3808-2
PMID: 30382443
Source: ProQuest One Psychology
Education Resources Information Center (ERIC)
MEDLINE
ProQuest Central

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Brief Report: Cannabidiol-Rich Cannabis in Children with Autism Spectrum Disorder and Severe Behavioral Problems—A Retrospective Feasibility Study

Springer Science+Business Media, LLC, part of Springer Nature 2018 ;COPYRIGHT 2019 Springer ;Journal of Autism and Developmental Disorders is a copyright of Springer, (2018). All Rights Reserved. ;ISSN: 0162-3257 ;EISSN: 1573-3432 ;DOI: 10.1007/s10803-018-3808-2 ;PMID: 30382443

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