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Gestational diabetes mellitus and risk of type 2 diabetes 10 years after the index pregnancy in Sri Lankan women-A community based retrospective cohort study

PloS one, 2017-06, Vol.12 (6), p.e0179647-e0179647 [Peer Reviewed Journal]

COPYRIGHT 2017 Public Library of Science ;COPYRIGHT 2017 Public Library of Science ;2017 Herath et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;2017 Herath et al 2017 Herath et al ;ISSN: 1932-6203 ;EISSN: 1932-6203 ;DOI: 10.1371/journal.pone.0179647 ;PMID: 28644881

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Title:
Gestational diabetes mellitus and risk of type 2 diabetes 10 years after the index pregnancy in Sri Lankan women-A community based retrospective cohort study
Author: Herath, Himali ; Herath, Rasika ; Wickremasinghe, Rajitha
Mellor, Duane
Subjects: Adolescent ; Adult ; Age Factors ; Biology and Life Sciences ; Birth Weight ; Complications and side effects ; Development and progression ; Diabetes ; Diabetes in pregnancy ; Diabetes mellitus ; Diabetes Mellitus, Type 2 - epidemiology ; Diabetes, Gestational - drug therapy ; Diabetes, Gestational - epidemiology ; Female ; Follow-Up Studies ; Genetic aspects ; Genetics ; Gestational age ; Gestational diabetes ; Glucose ; Health risk assessment ; Health risks ; Humans ; Incidence ; Insulin ; Insulin - therapeutic use ; Insulin resistance ; Internet ; Logistic Models ; Medical prognosis ; Medical records ; Medicine and Health Sciences ; Metabolism ; Middle Aged ; People and places ; Population ; Pregnancy ; Prevention ; Public health ; Retrospective Studies ; Risk ; Risk Factors ; Self Report ; Sri Lanka - epidemiology ; Studies ; Survival analysis ; Time Factors ; Type 2 diabetes ; Weighing ; Womens health ; Young Adult
Is Part Of: PloS one, 2017-06, Vol.12 (6), p.e0179647-e0179647
Description: Women with a history of gestational diabetes mellitus (GDM) have an increased risk of type 2 diabetes mellitus (T2DM) later in life compared to women with no GDM. This study was aimed to determine the risk of developing T2DM 10 years after GDM in Sri Lankan women. A retrospective cohort study was conducted in the Colombo district, Sri Lanka. 7205 women who delivered a child in 2005 were identified through Public Health Midwives in the field. Women with antenatal records were interviewed and relevant data were extracted from medical records to identify potential participants. One hundred and nineteen women who had GDM and 240 women who did not have GDM were recruited. Current diagnosis of diabetes was based on history, relevant medical records and blood reports within the past 1 year. The mean duration of follow up was 10.9 (SD = 0.35) years in the GDM group and 10.8 (SD = 0.31) years in the non-GDM group. The incidence density of diabetes in the GDM group was 56.3 per 1000 person years compared to 5.4 per 1000 person years in non GDM group giving a rate ratio of 10.42 (95% CI: 6.01-19.12). A woman having GDM in the index pregnancy was 10.6 times more likely to develop diabetes within 10 years compared to women with no GDM after controlling for other confounding variables. Delivering a child after 30 years, being treated with insulin during the pregnancy and delivering a baby weighing more than 3.5 Kg were significant predictors of development of T2DM after controlling for family history of diabetes mellitus (DM), GDM in previous pregnancies, parity and gestational age at delivery. Women with GDM had a 10-fold higher risk of developing T2DM during a 10-year follow up period as compared to women with no GDM after controlling for other confounding variables.
Publisher: United States: Public Library of Science
Language: English
Identifier: ISSN: 1932-6203
EISSN: 1932-6203
DOI: 10.1371/journal.pone.0179647
PMID: 28644881
Source: GFMER Free Medical Journals
MEDLINE
PubMed Central
Public Library of Science (PLoS)
ProQuest Central
DOAJ Directory of Open Access Journals

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Gestational diabetes mellitus and risk of type 2 diabetes 10 years after the index pregnancy in Sri Lankan women-A community based retrospective cohort study

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