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Predictive significance of standardized uptake value parameters of FDG-PET in patients with non-small cell lung carcinoma

Brazilian journal of medical and biological research, 2015-03, Vol.48 (3), p.267-272 [Peer Reviewed Journal]

COPYRIGHT 2015 Associacao Brasileira de Divulgacao Cientifica (ABDC) ;COPYRIGHT 2015 Associacao Brasileira de Divulgacao Cientifica (ABDC) ;This work is licensed under a Creative Commons Attribution 4.0 International License. ;ISSN: 0100-879X ;ISSN: 1414-431X ;EISSN: 1414-431X ;DOI: 10.1590/1414-431X20144137 ;PMID: 25651460

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Title:
Predictive significance of standardized uptake value parameters of FDG-PET in patients with non-small cell lung carcinoma
Author: Duan, X-Y ; Wang, W ; Li, M ; Li, Y ; Guo, Y-M
Subjects: 18F-FDG PET/CT ; Adult ; Aged ; Aged, 80 and over ; BIOLOGY ; Carcinoma, Non-Small-Cell Lung - diagnostic imaging ; Carcinoma, Non-Small-Cell Lung - metabolism ; Carcinoma, Non-Small-Cell Lung - pathology ; Care and treatment ; CAT scans ; Cell differentiation ; Clinical Investigation ; CT imaging ; Diagnosis ; Female ; Fluorodeoxyglucose F18 - pharmacokinetics ; Humans ; Lung cancer, Non-small cell ; Lung Neoplasms - diagnostic imaging ; Lung Neoplasms - metabolism ; Lung Neoplasms - pathology ; Male ; MEDICINE, RESEARCH & EXPERIMENTAL ; Middle Aged ; Neoplasm Staging ; Non-small cell lung cancer ; PET imaging ; Positron emission tomography ; Prediction ; Predictive Value of Tests ; Radiopharmaceuticals - pharmacokinetics ; Retrospective Studies ; Standardized uptake value (SUV)
Is Part Of: Brazilian journal of medical and biological research, 2015-03, Vol.48 (3), p.267-272
Description: (18)F-fluoro-2-deoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) is widely used to diagnose and stage non-small cell lung cancer (NSCLC). The aim of this retrospective study was to evaluate the predictive ability of different FDG standardized uptake values (SUVs) in 74 patients with newly diagnosed NSCLC. (18)F-FDG PET/CT scans were performed and different SUV parameters (SUVmax, SUVavg, SUVT/L, and SUVT/A) obtained, and their relationship with clinical characteristics were investigated. Meanwhile, correlation and multiple stepwise regression analyses were performed to determine the primary predictor of SUVs for NSCLC. Age, gender, and tumor size significantly affected SUV parameters. The mean SUVs of squamous cell carcinoma were higher than those of adenocarcinoma. Poorly differentiated tumors exhibited higher SUVs than well-differentiated ones. Further analyses based on the pathologic type revealed that the SUVmax, SUVavg, and SUVT/L of poorly differentiated adenocarcinoma tumors were higher than those of moderately or well-differentiated tumors. Among these four SUV parameters, SUVT/L was the primary predictor for tumor differentiation. However, in adenocarcinoma, SUVmax was the determining factor for tumor differentiation. Our results showed that these four SUV parameters had predictive significance related to NSCLC tumor differentiation; SUVT/L appeared to be most useful overall, but SUVmax was the best index for adenocarcinoma tumor differentiation.
Publisher: Brazil: Associacao Brasileira de Divulgacao Cientifica (ABDC)
Language: English;Portuguese
Identifier: ISSN: 0100-879X
ISSN: 1414-431X
EISSN: 1414-431X
DOI: 10.1590/1414-431X20144137
PMID: 25651460
Source: Geneva Foundation Free Medical Journals
PubMed Central (Open access)
SciELO
MEDLINE
DOAJ Directory of Open Access Journals

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Predictive significance of standardized uptake value parameters of FDG-PET in patients with non-small cell lung carcinoma

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