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New approach methodologies to enhance human health risk assessment of immunotoxic properties of chemicals - a PARC (Partnership for the Assessment of Risk from Chemicals) project

Frontiers in toxicology, 2024, Vol.6, p.1339104-1339104 [Peer Reviewed Journal]

Copyright © 2024 Snapkow, Smith, Arnesdotter, Beekmann, Blanc, Braeuning, Corsini, Sollner Dolenc, Duivenvoorde, Sundstøl Eriksen, Franko, Galbiati, Gostner, Grova, Gutleb, Hargitai, Janssen, Krapf, Lindeman, Lumniczky, Maddalon, Mollerup, Parráková, Pierzchalski, Pieters, Silva, Solhaug, Staal, Straumfors, Szatmári, Turner, Vandebriel, Zenclussen and Barouki. ;Copyright © 2024 Snapkow, Smith, Arnesdotter, Beekmann, Blanc, Braeuning, Corsini, Sollner Dolenc, Duivenvoorde, Sundstøl Eriksen, Franko, Galbiati, Gostner, Grova, Gutleb, Hargitai, Janssen, Krapf, Lindeman, Lumniczky, Maddalon, Mollerup, Parráková, Pierzchalski, Pieters, Silva, Solhaug, Staal, Straumfors, Szatmári, Turner, Vandebriel, Zenclussen and Barouki. 2024 Snapkow, Smith, Arnesdotter, Beekmann, Blanc, Braeuning, Corsini, Sollner Dolenc, Duivenvoorde, Sundstøl Eriksen, Franko, Galbiati, Gostner, Grova, Gutleb, Hargitai, Janssen, Krapf, Lindeman, Lumniczky, Maddalon, Mollerup, Parráková, Pierzchalski, Pieters, Silva, Solhaug, Staal, Straumfors, Szatmári, Turner, Vandebriel, Zenclussen and Barouki ;EISSN: 2673-3080 ;DOI: 10.3389/ftox.2024.1339104 ;PMID: 38654939

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Title:
New approach methodologies to enhance human health risk assessment of immunotoxic properties of chemicals - a PARC (Partnership for the Assessment of Risk from Chemicals) project
Author: Snapkow, Igor ; Smith, Nicola M ; Arnesdotter, Emma ; Beekmann, Karsten ; Blanc, Etienne B ; Braeuning, Albert ; Corsini, Emanuela ; Sollner Dolenc, Marija ; Duivenvoorde, Loes P M ; Sundstøl Eriksen, Gunnar ; Franko, Nina ; Galbiati, Valentina ; Gostner, Johanna M ; Grova, Nathalie ; Gutleb, Arno C ; Hargitai, Rita ; Janssen, Aafke W F ; Krapf, Solveig A ; Lindeman, Birgitte ; Lumniczky, Katalin ; Maddalon, Ambra ; Mollerup, Steen ; Parráková, Lucia ; Pierzchalski, Arkadiusz ; Pieters, Raymond H H ; Silva, Maria J ; Solhaug, Anita ; Staal, Yvonne C M ; Straumfors, Anne ; Szatmári, Tünde ; Turner, Jonathan D ; Vandebriel, Rob J ; Zenclussen, Ana Claudia ; Barouki, Robert
Subjects: immunosuppression ; immunotoxicology ; NAMs ; new approach methodologies ; PARC ; regulatory toxicology ; Toxicology
Is Part Of: Frontiers in toxicology, 2024, Vol.6, p.1339104-1339104
Description: As a complex system governing and interconnecting numerous functions within the human body, the immune system is unsurprisingly susceptible to the impact of toxic chemicals. Toxicants can influence the immune system through a multitude of mechanisms, resulting in immunosuppression, hypersensitivity, increased risk of autoimmune diseases and cancer development. At present, the regulatory assessment of the immunotoxicity of chemicals relies heavily on rodent models and a limited number of Organisation for Economic Co-operation and Development (OECD) test guidelines, which only capture a fraction of potential toxic properties. Due to this limitation, various authorities, including the World Health Organization and the European Food Safety Authority have highlighted the need for the development of novel approaches without the use of animals for immunotoxicity testing of chemicals. In this paper, we present a concise overview of ongoing efforts dedicated to developing and standardizing methodologies for a comprehensive characterization of the immunotoxic effects of chemicals, which are performed under the EU-funded Partnership for the Assessment of Risk from Chemicals (PARC).
Publisher: Switzerland: Frontiers Media S.A
Language: English
Identifier: EISSN: 2673-3080
DOI: 10.3389/ftox.2024.1339104
PMID: 38654939
Source: PubMed Central
DOAJ Directory of Open Access Journals

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New approach methodologies to enhance human health risk assessment of immunotoxic properties of chemicals - a PARC (Partnership for the Assessment of Risk from Chemicals) project

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