Language:

The Social Defeat Hypothesis of Schizophrenia: An Update

Schizophrenia bulletin, 2013-11, Vol.39 (6), p.1180-1186 [Peer Reviewed Journal]

2015 INIST-CNRS ;The Author 2013. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oup.com 2013 ;ISSN: 0586-7614 ;ISSN: 1745-1701 ;EISSN: 1745-1701 ;DOI: 10.1093/schbul/sbt134 ;PMID: 24062592 ;CODEN: SCZBB3

Full text available

Citations Cited by

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
The Social Defeat Hypothesis of Schizophrenia: An Update
Author: SELTEN, Jean-Paul ; VAN DER VEN, Elsje ; RUTTEN, Bart P. F ; CANTOR-GRAAE, Elizabeth
Subjects: Adult and adolescent clinical studies ; Biological and medical sciences ; Clinical Medicine ; dopamine ; Environment and Schizophrenia Invited ; epidemiology ; genetics ; Humans ; intelligence ; Klinisk medicin ; Medical and Health Sciences ; Medical sciences ; Medicin och hälsovetenskap ; migration ; Psychiatry ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Psychoses ; Psykiatri ; Schizophrenia ; Schizophrenia - epidemiology ; Schizophrenia - etiology ; social exclusion ; Social Marginalization - psychology
Is Part Of: Schizophrenia bulletin, 2013-11, Vol.39 (6), p.1180-1186
Description: According to the social defeat (SD) hypothesis, published in 2005, long-term exposure to the experience of SD may lead to sensitization of the mesolimbic dopamine (DA) system and thereby increase the risk for schizophrenia. The hypothesis posits that SD (ie, the negative experience of being excluded from the majority group) is the common denominator of 5 major schizophrenia risk factors: urban upbringing, migration, childhood trauma, low intelligence, and drug abuse. The purpose of this update of the literature since 2005 is to answer 2 questions: (1) What is the evidence that SD explains the association between schizophrenia and these risk factors? (2) What is the evidence that SD leads to sensitization of the mesolimbic DA system? The evidence for SD as the mechanism underlying the increased risk was found to be strongest for migration and childhood trauma, while the evidence for urban upbringing, low intelligence, and drug abuse is suggestive, but insufficient. Some other findings that may support the hypothesis are the association between risk for schizophrenia and African American ethnicity, unemployment, single status, hearing impairment, autism, illiteracy, short stature, Klinefelter syndrome, and, possibly, sexual minority status. While the evidence that SD in humans leads to sensitization of the mesolimbic DA system is not sufficient, due to lack of studies, the evidence for this in animals is strong. The authors argue that the SD hypothesis provides a parsimonious and plausible explanation for a number of epidemiological findings that cannot be explained solely by genetic confounding.
Publisher: Oxford: Oxford University Press
Language: English
Identifier: ISSN: 0586-7614
ISSN: 1745-1701
EISSN: 1745-1701
DOI: 10.1093/schbul/sbt134
PMID: 24062592
CODEN: SCZBB3
Source: GFMER Free Medical Journals
MEDLINE
PubMed Central
Alma/SFX Local Collection
SWEPUB Freely available online

Back to results list


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

The Social Defeat Hypothesis of Schizophrenia: An Update

Searching Remote Databases, Please Wait