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Relation of Black Race Between High Density Lipoprotein Cholesterol Content, High Density Lipoprotein Particles and Coronary Events (from the Dallas Heart Study)

The American journal of cardiology, 2015-04, Vol.115 (7), p.890-894 [Peer Reviewed Journal]

Elsevier Inc. ;2015 Elsevier Inc. ;Copyright © 2015 Elsevier Inc. All rights reserved. ;Copyright Elsevier Limited Apr 1, 2015 ;ISSN: 0002-9149 ;EISSN: 1879-1913 ;DOI: 10.1016/j.amjcard.2015.01.015 ;PMID: 25661572 ;CODEN: AJCDAG

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Title:
Relation of Black Race Between High Density Lipoprotein Cholesterol Content, High Density Lipoprotein Particles and Coronary Events (from the Dallas Heart Study)
Author: Chandra, Alvin, MD ; Neeland, Ian J., MD ; Das, Sandeep R., MD ; Khera, Amit, MD ; Turer, Aslan T., MD ; Ayers, Colby R., MS ; McGuire, Darren K., MD ; Rohatgi, Anand, MD
Subjects: Adult ; African Americans ; Aged ; Atherosclerosis - blood ; Atherosclerosis - ethnology ; Atoms & subatomic particles ; Cardiovascular ; Cardiovascular disease ; Cholesterol ; Cholesterol, HDL - blood ; Cholesterol, LDL - blood ; Coronary Artery Disease - blood ; Coronary Artery Disease - ethnology ; Female ; Heart attacks ; Hormone replacement therapy ; Humans ; Incidence ; Male ; Middle Aged ; Population Surveillance ; Prevalence ; Prospective Studies ; Risk Assessment - methods ; Risk Factors ; Texas - epidemiology
Is Part Of: The American journal of cardiology, 2015-04, Vol.115 (7), p.890-894
Description: Therapies targeting high-density lipoprotein cholesterol content (HDL-C) have not improved coronary heart disease (CHD) outcomes. High-density lipoprotein particle concentration (HDL-P) may better predict CHD. However, the impact of race/ethnicity on the relations between HDL-P and subclinical atherosclerosis and incident CHD events has not been described. Participants from the Dallas Heart Study (DHS), a multiethnic, probability-based, population cohort of Dallas County adults, underwent the following baseline measurements: HDL-C, HDL-P by nuclear magnetic resonance imaging, and coronary artery calcium by electron-beam computed tomography. Participants were followed for a median of 9.3 years for incident CHD events (composite of first myocardial infarction, stroke, coronary revascularization, or cardiovascular death). The study comprised 1,977 participants free of CHD (51% women, 46% black). In adjusted models, HDL-C was not associated with prevalent coronary artery calcium (p = 0.13) or incident CHD overall (hazard ratio [HR] per 1 SD 0.89, 95% confidence interval [CI] 0.76 to 1.05). However, HDL-C was inversely associated with incident CHD among nonblack (adjusted HR per 1 SD 0.67, 95% CI 0.46 to 0.97) but not black participants (HR 0.94, 95% CI 0.78 to 1.13, pinteraction = 0.05). Conversely, HDL-P, adjusted for risk factors and HDL-C, was inversely associated with prevalent coronary artery calcium (p = 0.009) and with incident CHD overall (adjusted HR per 1 SD 0.73, 95% CI 0.62 to 0.86), with no interaction by black race/ethnicity (pinteraction = 0.57). In conclusion, in contrast to HDL-C, the inverse relation between HDL-P and incident CHD events is consistent across ethnicities. These findings suggest that HDL-P is superior to HDL-C in predicting prevalent atherosclerosis as well as incident CHD events across a diverse population and should be considered as a therapeutic target.
Publisher: United States: Elsevier Inc
Language: English
Identifier: ISSN: 0002-9149
EISSN: 1879-1913
DOI: 10.1016/j.amjcard.2015.01.015
PMID: 25661572
CODEN: AJCDAG
Source: MEDLINE
ProQuest Central

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Relation of Black Race Between High Density Lipoprotein Cholesterol Content, High Density Lipoprotein Particles and Coronary Events (from the Dallas Heart Study)

Elsevier Inc. ;2015 Elsevier Inc. ;Copyright © 2015 Elsevier Inc. All rights reserved. ;Copyright Elsevier Limited Apr 1, 2015 ;ISSN: 0002-9149 ;EISSN: 1879-1913 ;DOI: 10.1016/j.amjcard.2015.01.015 ;PMID: 25661572 ;CODEN: AJCDAG

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